β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins

Wei Chen; Liaoyuan A. Hu; Mikhail V. Semenov

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β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins

机译：β-Arrestin1通过与磷酸化的斑驳蛋白相互作用来调节淋巴增强因子转录活性

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One aspect of the function of the β-arrestins is to serve as scaffold or adapter molecules coupling G-protein coupled receptors (GPCRs) to signal transduction pathways distinct from traditional second messenger pathways. Here we report the identification of Dishev- elled 1 and Dishevelled 2 (Dvl1 and Dvl2) as β-arrestin1 (βarr1) interacting proteins. Dvl proteins participate as key intermediates in signal transmission from the seven membrane-spanning Frizzled receptors leading to inhibition of glycogen synthase kinase-3β (GSK-3β), stabilization of β-catenin, and activation of the lymphoid enhancer factor (LEF) transcription factor.

机译：β-arrestin功能的一方面是用作将G蛋白偶联受体（GPCR）偶联至不同于传统第二信使途径的信号转导途径的支架或衔接子分子。在这里，我们报告鉴定Dishevelled 1和Disheveled 2（Dvl1和Dvl2）为β-arrestin1（βarr1）相互作用蛋白。 Dvl蛋白作为关键中间体参与来自七个跨膜卷曲蛋白受体的信号传递，从而导致糖原合酶激酶-3β（GSK-3β）的抑制，β-catenin的稳定和淋巴增强因子（LEF）转录因子的激活。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第26期|p.14889-14894|共6页
作者
Wei Chen; Liaoyuan A. Hu; Mikhail V. Semenov;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：毛发/分裂相关蛋白增强剂与胰腺转录因子Ptf1-p48之间的相互作用调节PTF1转录复合物的功能
2. Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex. [J] . Ghosh B, Leach SD The Biochemical Journal . 2006,第Pta3期

机译：分裂相关蛋白的毛状/增强子与胰腺转录因子Ptf1-p48之间的相互作用调节PTF1转录复合物的功能。
3. Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors. [J] . Meraro D, Hashmueli S, Koren B, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第12期

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4. Mapping the Sites of Interaction of a Hub Protein in a Transcription Factor Protein Interaction Network using the HaloTag [C] . Charles A. S. Banks, Gina Boanca, Zachary Lee, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

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5. Protein-protein and protein -DNA interactions of the b /HLH/z transcription factors Myc /Max /Mad. [D] . Hu, Jianzhong. 2004

机译：b / HLH / z转录因子Myc / Max / Mad的蛋白质-蛋白质和蛋白质-DNA相互作用。
6. β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins [O] . Wei Chen, Liaoyuan A. Hu, Mikhail V. Semenov, 2001

机译：β-Arrestin1调节淋巴增强因子转录通过与磷酸化的衣衫proteins蛋白相互作用而产生活性
7. β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins [O] . Chen, Wei, Hu, Liaoyuan A., Semenov, Mikhail V., 2001

机译：β-Arrestin1调节淋巴增强因子转录通过与磷酸化的衣衫proteins蛋白相互作用而产生活性

β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins

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