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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >In vivo natural killer cell activities revealed by natural killer cell-deficient mice
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In vivo natural killer cell activities revealed by natural killer cell-deficient mice

机译：缺乏自然杀伤细胞的小鼠体内的自然杀伤细胞活性

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摘要

Studies of natural killer (NK) cell function in vivo have been challenging primarily due to the lack of animal models in which NK cells are genetically and selectively deficient. Here, we describe a transgenic mouse with defective natural killing and selective deficiency in NK1.1+ CD3- cells. Despite functionally normal B, T, and NK/T cells, transgenic mice displayed impaired acute in vivo rejection of tumor cells. Adoptive transfer experiments confirmed that NK1.1 + CD3- cells were responsible for acute tumor rejection, establishing the relationship of NK1.1+ CD3- cells to NK cells. Additional studies provided evidence that (i) NK cells play an important role in suppressing tumor metastasis and outgrowth; (ii) NK cells are major producers of lFNγ in response to bacterial endotoxin but not to interleukin-12, and; (iii) NK cells are not essential for humoral responses to T cell-independent type 2 antigen or the generalized Shwartzman reaction, both of which were previously proposed to involve NK cells.
机译：体内天然杀伤（NK）细胞功能的研究具有挑战性，这主要是由于缺乏NK细胞具有遗传和选择性缺陷的动物模型所致。在这里，我们描述了具有缺陷的自然杀伤力和NK1.1 + CD3-细胞选择性缺陷的转基因小鼠。尽管功能正常的B，T和NK / T细胞正常运转，转基因小鼠仍表现出对肿瘤细胞的急性体内排斥反应。过继转移实验证实，NK1.1 + CD3-细胞是导致急性肿瘤排斥的原因，建立了NK1.1 + CD3-细胞与NK细胞的关系。其他研究提供了证据：（i）NK细胞在抑制肿瘤转移和生长中起重要作用； （ii）NK细胞是对细菌内毒素而非白介素12产生反应的主要iFNγ产生者；以及（iii）NK细胞对于非T细胞非依赖性2型抗原的体液反应或广义Shwartzman反应不是必不可少的，这两种反应先前都被认为涉及NK细胞。

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