Genomic engineering: moving beyond DNA sequence to function

Fitch J.P.; Sokhansanj B.

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Genomic engineering: moving beyond DNA sequence to function

机译：基因组工程：超越DNA序列发挥功能

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摘要

The DNA sequence of the human genome has been determined. This significant scientific milestone has been a multidisciplinary effort sponsored by both public and private investments. Engineering and computer science contributions have been essential to success, especially with the accelerated schedules of the Human Genome Project. A tutorial summary of the biological and health implications of sequencing the human genome is presented together with examples of how genome data from human and other organisms are already used. Engineering contributions to sequencing are identified as well as predictions of how engineering methods may contribute to the "postsequencing" era of biology.

机译：已经确定了人类基因组的DNA序列。这个重要的科学里程碑是公共和私人投资共同发起的一项多学科努力。工程和计算机科学的贡献对于成功至关重要，特别是随着人类基因组计划进度的加快。介绍了对人类基因组测序的生物学和健康影响的教程摘要，以及如何使用人类和其他生物的基因组数据的示例。确定了对测序的工程贡献以及对工程方法如何有助于生物学的“后测序”时代的预测。

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来源
《Proceedings of the IEEE》 |2000年第12期|P.1949-1971|共23页
作者
Fitch J.P.; Sokhansanj B.;
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作者单位

Lawrence Livermore Nat. Lab., CA;

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原文格式 PDF
正文语种 eng
中图分类一般性问题;无线电电子学、电信技术;
关键词
DNA; cellular biophysics; molecular biophysics; proteins; reviews; stochastic systems; DNA sequence; Human Genome Project; biological and health implications; computer science; genomic engineering; health implications; human genome; postsequencing; protein; stochastic simulation; tutorial summary;

机译：DNA;细胞生物物理学;分子生物物理学;蛋白质;综述;随机系统;DNA序列;人类基因组计划;生物学和健康影响;计算机科学;基因组工程;健康影响;人类基因组;后测序;蛋白质;随机模拟;教程摘要;

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专利

1. Prolog to genomic engineering: moving beyond DNA sequence to function [J] . Esch J. Proceedings of the IEEE . 2000,第12期

机译：基因工程的序幕：超越DNA序列发挥功能
2. Functional expression of the genomic DNA sequences encoding mouse Na,K-ATPase alpha 1 gene by cotransfection of overlapping genomic DNA segments. [J] . S Y Tam, E N Geissler, S L Graw, Molecular and Cellular Biology . 1990,第12期

机译：通过共转染重叠的基因组DNA片段，编码小鼠Na，K-ATPase alpha 1基因的基因组DNA序列的功能表达。
3. DNA SEQUENCING AND COMPARATIVE SEQUENCE ANALYSIS REVEAL THAT THE ESCHERICHIA COLI GENOMIC DNA MAY REPLACE THE TARGET DNA DURING MOLECULAR CLONING - EVIDENCE FOR THE ERRONEOUS ASSEMBLY OF E-COLI DNA INTO DATABASE SEQUENCES [J] . Jha PK., Sarkar S. Comparative biochemistry and physiology, Part B. Biochemistry & molecular biology . 1997,第2期

机译：DNA测序和比较序列分析表明，大肠埃希氏菌基因组DNA可能在分子克隆过程中取代目标DNA-证据表明E-Coli DNA已错误地组装到数据库序列中
4. An Efficient System for Finding Functional Motifs in Genomic DNA Sequences by Using Nature-Inspired Algorithms [C] . Ebtehal S. Elewa, Mohamed B. Abdelhalim, Mai S. Mabrouk International Conference on Advanced Intelligent Systems and Informatics . 2017

机译：利用自然启发算法在基因组DNA序列中寻找功能基序的有效系统
5. Isolation and characterization of genomic DNA sequences that enhance the stability of plasmid DNA in mammalian cells. [D] . Manocha, Marcus M. S. 2006

机译：增强哺乳动物细胞中质粒DNA稳定性的基因组DNA序列的分离和表征。
6. Functional expression of the genomic DNA sequences encoding mouse NaK-ATPase alpha 1 gene by cotransfection of overlapping genomic DNA segments. [O] . S Y Tam, E N Geissler, S L Graw, 1990

机译：通过共转染重叠的基因组DNA片段编码小鼠NaK-ATPase alpha 1基因的基因组DNA序列的功能表达。
7. Functional expression of the genomic DNA sequences encoding mouse Na,K-ATPase alpha 1 gene by cotransfection of overlapping genomic DNA segments. [O] . Tam, S Y, Geissler, E N, Graw, S L, 1990

机译：通过共转染重叠的基因组DNA片段，编码小鼠Na，K-ATPase alpha 1基因的基因组DNA序列的功能表达。
8. DNA in Chromatin: How to Extract Structural, Dynamical and Functional Information from the Analysis of Genomic Sequences using Space-Scale Wavelet Techniques [R] . Arneodo, A. , Argoul, F. , Audit, B. , 2005

机译：染色质中的DNa：如何利用空间尺度小波技术从基因组序列分析中提取结构，动力学和功能信息

Genomic engineering: moving beyond DNA sequence to function

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