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首页> 外文期刊>Process Biochemistry >Pd nanoparticles and molybdenum disulfide (MoS_2) integrated sensing platform for the detection of neuromodulator
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Pd nanoparticles and molybdenum disulfide (MoS_2) integrated sensing platform for the detection of neuromodulator

机译：钯纳米颗粒和二硫化钼（MoS_2）集成传感平台，用于检测神经调节剂

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Acetylcholine (ACh) present inside the brain has ability to alter neuronal activation, influencing transmission of synapse by inducing neurons causing the enhancement in the ability of neuronal networks inside the brain. In result, ACh modifies the response of internal and external environment and perform function as a neuromodulator. This empowers the plan of a sensor particular for ACh that is effectively brought into biological frameworks. The work described here, an acetylcholinesterase (AChe) based sensor which is the most promising tool for analysis of neuromodulator level in biological samples. The prepared biosensor interface is based on co-immobilization of the AChe and choline oxidase (Cho) onto palladium nanoparticles (Pd-nano) adsorbed over molybdenum disulfide (MoS2) nanostructures electrodeposited on the surface of gold electrode (Au-ET). The sensor had excellent linear range of 1.0 nM to 10 niM with 1.0 nM as limit of detection. The novel AChe-Cho/Pdnano/MoS2@Au-ET shows a tremendous potential for applications in medical research and clinical diagnosis. The novel biosensor formed has good accuracy, precision and reliability hence, it might provide a new outlook for the detection and recognition of ACh in real serum samples.
机译：脑内存在的乙酰胆碱（ACh）具有改变神经元激活的能力，通过诱导神经元引起脑内神经元网络能力的增强来影响突触的传递。结果，ACh改变了内部和外部环境的反应，并起到了神经调节剂的作用。这使专用于ACh的传感器计划成为可能，该计划已被有效地纳入生物学框架。这里描述的工作是一种基于乙酰胆碱酯酶（AChe）的传感器，它是分析生物样品中神经调节剂水平的最有前途的工具。制备的生物传感器界面基于将AChe和胆碱氧化酶（Cho）固定在吸附在电沉积在金电极（Au-ET）表面的二硫化钼（MoS2）纳米结构上的钯纳米颗粒（Pd-nano）上。该传感器具有1.0 nM至10 niM的出色线性范围，其中1.0 nM作为检测限。新颖的AChe-Cho / Pdnano / MoS2 @ Au-ET显示出在医学研究和临床诊断中的巨大潜力。所形成的新型生物传感器具有良好的准确性，准确性和可靠性，因此，它可能为检测和识别真实血清样品中的乙酰胆碱提供新的前景。

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