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首页> 外文期刊>Psychological medicine >A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients.
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A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients.

机译：多巴胺转运蛋白多态性是抑郁症患者边缘型人格障碍的危险因素。

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BACKGROUND: Borderline personality disorder (BPD) is often co-morbid with major depression and may complicate its treatment. We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD. METHOD: Out-patients with major depressive disorder were recruited for two treatment trials. Assessment of depressed patients included the assessment of personality disorders, developmental risk factors and DNA samples for genetic analyses. RESULTS: In each study there was a significant association between the 9-repeat allele of the dopamine transporter (DAT1) and BPD, with odds ratios (OR) > 3 and p < or = 0.02. This association remained significant when developmental risk factors for BPD (childhood abuse and neglect and borderline temperament) were also included in the analyses. The OR was even larger in the depressed patients aged > or = 35 years (OR 9.31, p = 0.005). CONCLUSION: This replicated association in depressed patients between the 9-repeat allele of DAT1 and BPD may provide clues to understanding the neurobiology of BPD. The finding that the association is larger in the older depressed patients, suggests that the 9-repeat allele may be associated with a poorer prognosis BPD, rather than a young adult limited variant of BPD.
机译：背景：边缘性人格障碍（BPD）通常与重度抑郁症并存，可能会使其治疗复杂化。我们对患有或不患有合并BPD的抑郁症患者之间遗传和发育危险因素的差异感兴趣。方法：招募患有重度抑郁症的门诊患者进行两项治疗试验。对抑郁症患者的评估包括人格障碍，发育危险因素和DNA样本的遗传分析评估。结果：在每项研究中，多巴胺转运蛋白的9重复等位基因（DAT1）与BPD之间存在显着相关性，比值比（OR）> 3和p <或= 0.02。当分析中还包括BPD的发育危险因素（儿童虐待，忽视和边缘性气质）时，这种关联仍然很重要。在≥35岁的抑郁患者中，OR甚至更大（OR 9.31，p = 0.005）。结论：DAT1和BPD的9重复等位基因在抑郁症患者中的这种重复关联可能为了解BPD的神经生物学提供了线索。在老年抑郁症患者中相关性更大的发现表明，9重复等位基因可能与较差的BPD预后相关，而不是与BPD的年轻成人受限变体相关。

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