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首页> 外文期刊>Quality of Life Research >Reliability and validity of functional health status and health-related quality of life questionnaires in children with recurrent acute otitis media
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Reliability and validity of functional health status and health-related quality of life questionnaires in children with recurrent acute otitis media

机译：复发性急性中耳炎患儿功能健康状况和健康相关生活质量调查问卷的信度和效度

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摘要

In this study the reliability and validity of generic and disease-specific questionnaires has been assessed focusing on responsiveness. This is part of a study on the effects of recurrent acute otitis media (rAOM) on functional health status (FHS) and health-related quality of life (HRQoL) in 383 children with rAOM participating in a randomized clinical trial. The following generic questionnaires were studied: 1. RAND general health rating index, 2. Functional Status Questionnaire (FSQ Generic and FSQ Specific), 3. TNO-AZL Infant Quality of Life (TAIQOL), and the following disease-specific questionnaires: 1. Otitis Media-6 (OM-6), 2. Numerical rating scales (NRS) for child and caregiver (NRS Child and NRS Caregiver), and 3. a new Family Functioning Questionnaire (FFQ). Reliability was good to excellent (Cronbach’s α range 0.80–0.90, intraclass correlation coefficient range 0.76–0.93). Moderate to strong correlations were found between the questionnaires as well as between questionnaires and relevant clinical indicators (r = 0.29–0.49), demonstrating construct validity. Discriminant validity for children with few versus frequent episodes of acute otitis media per year was good for most questionnaires (P < 0.004) but poor for the otitis media-related subscales of the TAIQOL (P = 0.10–0.97) and both NRS (P = 0.22 and 0.48). Except for the TAIQOL subscales, change scores were significant (P < 0.003) for generic and disease-specific questionnaires. Effect sizes were somewhat higher for disease-specific compared to generic questionnaires (0.55–0.95 versus 0.32–0.60) except for the TAIQOL subscales, which showed very poor sensitivity to change. Anchor-based methods resulted in a somewhat larger range of estimates of MCID than distribution-based methods. Combining distribution-based and anchor-based methods resulted in similar ranges for the minimally clinical important differences for generic and disease-specific questionnaires: 2–15 points on a 0–100 scale. Apart from the generic TAIQOL subscales, both generic and disease-specific questionnaires used in this study showed good psychometric qualities and responsiveness for use in clinical studies on children with rAOM.
机译：在这项研究中，一般和针对特定疾病的调查问卷的信度和效度已集中在响应能力上。这是一项针对参与随机临床试验的383名患有rAOM的儿童中复发性急性中耳炎（rAOM）对功能健康状况（FHS）和与健康相关的生活质量（HRQoL）的影响的研究的一部分。研究了以下通用问卷：1. RAND总体健康等级指数； 2.功能状态问卷（FSQ通用和FSQ特定）； 3. TNO-AZL婴儿生活质量（TAIQOL）；以及以下特定疾病的问卷：1中耳炎6（OM-6）； 2。儿童和保姆的数字评分量表（NRS）（儿童和NRS的保姆），以及3.新的家庭功能问卷（FFQ）。可靠性好到极好（Cronbach的α范围为0.80-0.90，组内相关系数范围为0.76-0.93）。问卷之间以及问卷和相关临床指标之间均存在中等至强相关性（r = 0.29–0.49），证明了结构的有效性。对于大多数问卷，每年很少或频繁发作急性中耳炎的儿童的判别有效性很好（P <0.004），但对TAIQOL中耳炎相关的子量表（P = 0.10–0.97）和NRS两者均较差（P = 0.22和0.48）。除TAIQOL分量表外，通用问卷和疾病特定问卷的变化得分均显着（P <0.003）。除TAIQOL子量表对变化的敏感性非常差以外，与一般性调查表相比，针对疾病的影响大小要高一些（0.55-0.95对0.32-0.60）。与基于分布的方法相比，基于锚的方法对MCID的估计范围更大。基于分布和基于锚的方法相结合，得出针对通用问卷和针对特定疾病的问卷的最小临床重要差异的相似范围：0–100范围内的2–15分。除了通用的TAIQOL分量表之外，本研究中使用的通用和针对特定疾病的调查问卷还显示出良好的心理测量质量和反应性，可用于rAOM儿童的临床研究。

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  • 来源
    《Quality of Life Research》 |2007年第8期|1357-1373|共17页
  • 作者

    Carole N. M. Brouwer; Anne G. M. Schilder; Henk F. van Stel; Maroeska M. Rovers; Reinier H. Veenhoven; Diederick E. Grobbee; Elisabeth A. M. Sanders; A. Rianne Maillé;

  • 作者单位

    Department of Paediatrics Spaarne Hospital Postbus 770 2130 AT Hoofddorp The Netherlands;

    Department of Otorhinolaryngology Wilhelmina Children’s Hospital/University Medical Center Utrecht Utrecht The Netherlands;

    Julius Center for Health Sciences and Primary Care University Medical Center Utrecht P.O. Box 85500 3508 GA Utrecht The Netherlands;

    Julius Center for Health Sciences and Primary Care University Medical Center Utrecht P.O. Box 85500 3508 GA Utrecht The Netherlands;

    Department of Paediatrics Spaarne Hospital Postbus 770 2130 AT Hoofddorp The Netherlands;

    Julius Center for Health Sciences and Primary Care University Medical Center Utrecht P.O. Box 85500 3508 GA Utrecht The Netherlands;

    Department of Paediatric Immunology Wilhelmina Children’s Hospital/University Medical Center Utrecht Utrecht The Netherlands;

    Julius Center for Health Sciences and Primary Care University Medical Center Utrecht P.O. Box 85500 3508 GA Utrecht The Netherlands;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Childhood infection; Acute otitis media; Functional health status; Quality of life; Reliability; Validity; Responsiveness;

    机译：儿童感染;急性中耳炎;功能健康状况;生活质量;可靠性;有效性;反应性;

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