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首页> 外文期刊>Radiation Protection and Environment >Radioprotective potential of Decalepis hamiltonii: A study on gamma radiation-induced oxidative stress and toxicity in Drosophila melanogaster
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Radioprotective potential of Decalepis hamiltonii: A study on gamma radiation-induced oxidative stress and toxicity in Drosophila melanogaster

机译：十足拟Dec虫的辐射防护潜​​力：对黑腹果蝇γ射线诱导的氧化应激和毒性的研究

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摘要

Radiation-induced damage to normal tissues restricts the therapeutic use of radiation in clinical application for cancer treatment and thereby limits the efficacy of the treatment. The use of chemical compounds as radioprotectors is a desirable strategy to improve the therapeutic index of radiotherapy. However, most of the synthetic radioprotective compounds studied have shown to have undesirable properties of toxicity. There is a need for safer, natural radioprotective agents without compromising efficacy of the treatment. We have investigated the radioprotective potential of Decalepis hamiltonii (Dh) root extract which is rich in natural antioxidants by employing Drosophila melanogaster as a model. Irradiation of Drosophila with 100, 200, and 400 Gy of gamma radiation induced dose-dependent mortality. Elevation in the levels of thiobarbituric acid reactive substances (TBARS), the activities of catalase (CAT) and superoxide dismutase (SOD), and depletion of glutathione (GSH) content suggested radiation-induced oxidative stress. Pretreatment of flies with Dh root extract protected them from radiation-induced mortality and oxidative stress as evidenced by reduction in TBARS and restoration of the antioxidant enzymes, SOD and CAT, and GSH to control levels. This is the first report of radioprotective action of Dh root extract in D. melanogaster.
机译：辐射诱导的对正常组织的损害限制了辐射在癌症治疗的临床应用中的治疗用途，从而限制了治疗的功效。使用化合物作为放射防护剂是改善放射疗法的治疗指数的理想策略。但是，研究的大多数合成放射防护化合物都显示出不良的毒性。需要更安全的天然放射防护剂而不损害治疗功效。我们已经通过采用果蝇果蝇为模型，研究了富含天然抗氧化剂的十足十足草（Dalalepis hamiltonii（Dh））根提取物的辐射防护潜​​力。用100、200和400 Gy的伽马射线照射果蝇会引起剂量依赖性死亡率。硫代巴比妥酸反应性物质（TBARS）的水平升高，过氧化氢酶（CAT）和超氧化物歧化酶（SOD）的活性以及谷胱甘肽（GSH）含量的减少表明了辐射引起的氧化应激。用Dh根提取物对果蝇进行预处理可以使它们免受辐射诱导的死亡和氧化应激，这通过降低TBARS以及将抗氧化酶，SOD和CAT以及GSH恢复到控制水平来证明。这是Dh根提取物对黑腹果蝇的辐射防护作用的首次报道。

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