1-(p-Fluorophenyl)-2-(2′-pyridyl)ethanol and 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene obtained from the condensation reaction of 2-picoline and p-fluorophenylaldehyde under catalyst-and solvent-free conditions

M. Judith Percino; Víctor M. Chapela; Omar Urzúa; Ling-Fa Montiel; Cecilia Rodríguez-Barbarín

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1-(p-Fluorophenyl)-2-(2′-pyridyl)ethanol and 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene obtained from the condensation reaction of 2-picoline and p-fluorophenylaldehyde under catalyst-and solvent-free conditions

机译：2-甲基吡啶与对氟苯甲醛在催化剂下的缩合反应获得的1-（对氟苯基）-2-（2'-吡啶基）乙醇和1-（对氟苯基）-2-（2'-吡啶基）乙烯-无溶剂条件

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The novel intermediate 1-(p-fluorophenyl)-2-(2′-pyridyl)ethanol or 2-[2′-(1-hydroxy-1-(p-fluorophenyl)ethyl]pyridine and the corresponding novel dehydration compound 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene or 2-[p-fluorophenylvinyl]pyridine were obtained from the condensation reaction of p-fluorophenylaldehyde and 2-picoline under catalyst-and solvent-free conditions. The intermediate 1-(p-fluorophenyl)-2-(2′-pyridyl)ethanol was obtained at 42 h reaction time and temperature of 120°C, respectively. 1H-NMR, IR spectroscopic data of the 1-(p-fluorophenyl)-2-(2-pyridyl)ethanol clearly showed the presence of the-CH2-CHOH-group. The compound was obtained as a white powder with m.p. 121–122°C and a yield of 8%. For 1-(p-fluorophenyl)-2-(2-pyridyl)ethene, the reaction conditions were similar, but the reaction temperature was increased to yield the double bond in the 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene. At the reaction temperature of 140°C, the compound was a slightly brown powder with a m.p. of 78°C and yield of 18%. 1H-NMR, IR spectroscopic data for the 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene showed the presence of a double bond in trans configuration (-CH=CH-), characteristic of a styrylpyridine.

机译：新型中间体1-（对氟苯基）-2-（2'-吡啶基）乙醇或2- [2'-（1-羟基-1-（对氟苯基）乙基]吡啶和相应的新型脱水化合物1-在无催化剂和无溶剂的条件下，由对氟苯甲醛与2-甲基吡啶的缩合反应制得（对氟苯基）-2-（2'-吡啶基）乙烯或2- [对氟苯基乙烯基]吡啶。 -（对氟苯基）-2-（2'-吡啶基）乙醇分别在42 h反应时间和120°C的温度下获得。1-（p的1 H-NMR，IR光谱数据-氟苯基）-2-（2-吡啶基）乙醇清楚地表明-CH2 -CHOH-基团的存在，该化合物为白色粉末，熔点121-122℃，收率8％对于1-（对氟苯基）-2-（2-吡啶基）乙烯，反应条件相似，但是提高了反应温度以在1-（对氟苯基）-2-（2）中产生双键。 '-吡啶基）乙烯在140°C的反应温度下，该化合物为浅棕色粉末der m.p.熔点为78℃，产率为18％。 1-（对氟苯基）-2-（2'-吡啶基）乙烯的1 H-NMR，IR光谱数据表明存在反式双键（-CH = CH-），具有特征苯乙烯基吡啶。

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来源
《Research on Chemical Intermediates》 |2007年第7期|623-629|共7页
作者
M. Judith Percino; Víctor M. Chapela; Omar Urzúa; Ling-Fa Montiel; Cecilia Rodríguez-Barbarín;
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Centro de Química Instituto de Ciencias Universidad Autónoma de Puebla Complejo de Ciencias ICUAP Edif. 194 22 Sur y San. Claudio C.P. 72570 Puebla Puebla México;

Centro de Química Instituto de Ciencias Universidad Autónoma de Puebla Complejo de Ciencias ICUAP Edif. 194 22 Sur y San. Claudio C.P. 72570 Puebla Puebla México;

Centro de Química Instituto de Ciencias Universidad Autónoma de Puebla Complejo de Ciencias ICUAP Edif. 194 22 Sur y San. Claudio C.P. 72570 Puebla Puebla México;

Centro de Química Instituto de Ciencias Universidad Autónoma de Puebla Complejo de Ciencias ICUAP Edif. 194 22 Sur y San. Claudio C.P. 72570 Puebla Puebla México;

División de Estudios de Posgrado Facultad de Ciencias Químicas U.A.N.L. Guerrero y Progreso S/N Col. Treviño C.P. 64570 Monterrey N.L. México;

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正文语种 eng
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1-(p-fluorophenyl)-2-(2′-pyridyl)ethanol; 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene; intermediate; stilbazole; methylpyridines; fluorobenzaldehyde;

机译：1-（对氟苯基）-2-（2'-吡啶基）乙醇;1-（对氟苯基）-2-（2'-吡啶基）乙烯;中间体;噻唑;甲基吡啶;氟苯甲醛;

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1. 1-(p-Fluorophenyl)-2-(2 '-pyridyl)ethanol and 1-(p-fluorophenyl)-2-(2 '-pyridyl)ethene obtained from the condensation reaction of 2-picoline and p-fluorophenylaldehyde under catalyst- and solvent-free conditions [J] . Percino MJ, Chapela VM, Urzua O, Research on Chemical Intermediates . 2007,第7期

机译：2-甲基吡啶与对氟苯甲醛在催化剂下的缩合反应得到的1-（对氟苯基）-2-（2'-吡啶基）乙醇和1-（对氟苯基）-2-（2'-吡啶基）乙烯-无溶剂条件
2. X-Ray Crystal Structures of a 1-(p-fluorophenyl)-2-(α-pyridyl)ethanol Intermediate and the 1-(p-fluorophenyl)-2-(α-pyridyl)ethene Dehydration Compound Obtained from the Condensation Reaction of 2-Methylpyridine and p-Fluorobenzaldehyde [J] . M.Judith Percino, Víctor M. Chapela, Ling-FaMontiel, The Open Crystallography Journal . 2008,第1期

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1-(p-Fluorophenyl)-2-(2′-pyridyl)ethanol and 1-(p-fluorophenyl)-2-(2′-pyridyl)ethene obtained from the condensation reaction of 2-picoline and p-fluorophenylaldehyde under catalyst-and solvent-free conditions

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