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首页> 外文期刊>Reviews in Endocrine and Metabolic Disorders >Toxic chemicals and thyroid function: hard facts and lateral thinking
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Toxic chemicals and thyroid function: hard facts and lateral thinking

机译：有毒化学物质和甲状腺功能：事实和侧面思考

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Increasing quantities of evidence-based data incriminate a large number of environmental pollutants for toxic effects on the thyroid. Among the many chemical contaminants, halogenated organochlorines and pesticides variably affect the hypothalamic-pituitary-thyroid axis and disrupt thyroid function. PCBs and their metabolites and PBDEs bind to thyroid transport proteins, such as transthyretin, displace thyroxine, and disrupt thyroid function. Meanwhile, at the molecular level, PCB congeners may activate phosphorylation of Akt, p-Akt, and forkhead box O3a (FoxO3a) protein resulting in inhibition of the natrium/iodide symporter. Given therefore the growing concern developing around these multiple toxic chemicals today invading numerous environments and their long-term deleterious effects not only on the thyroid but also on general health, we strongly advocate their strict regulation and, moreover, their gradual reduction. A good degree of “lateral thinking”, we feel, will lead to a use of chemicals that will enhance life while concurrently carefully protecting the environment.
机译：越来越多的循证数据表明，大量环境污染物对甲状腺有毒作用。在许多化学污染物中，卤代有机氯和农药会影响下丘脑-垂体-甲状腺轴并破坏甲状腺功能。多氯联苯及其代谢产物和多溴二苯醚与甲状腺转运蛋白（如运甲状腺素蛋白）结合，置换甲状腺素并破坏甲状腺功能。同时，在分子水平上，PCB同源物可能激活Akt，p-Akt和叉头盒O3a（FoxO3a）蛋白的磷酸化，从而导致钠/碘同向转运蛋白的抑制。因此，鉴于当今围绕这些多种有毒化学物质的发展引起越来越多的关注，这些化学物质已经侵入许多环境，并且它们不仅对甲状腺而且对整体健康都具有长期有害影响，因此，我们强烈主张严格控制并逐步减少它们。我们认为，高度的“横向思考”将导致使用化学物质，这些物质可以改善生活，同时还应谨慎保护环境。

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