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首页> 外文OA文献 >Protective effect of L-ornithine-L-aspartate and silymarin on chemically induced kidney toxicity and thyroid dysfunction in mice
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Protective effect of L-ornithine-L-aspartate and silymarin on chemically induced kidney toxicity and thyroid dysfunction in mice

机译：L-鸟氨酸-L-天冬氨酸和水飞蓟素对化学诱导的小鼠肾脏毒性和甲状腺功能障碍的保护作用

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摘要

The present study was designed to reveal the hitherto unknown efficacy of two commonlyused hepatoprotective drugs, L-ornithine-L-aspartate (lornit) and silymarin in the regulation ofkidney toxicity and thyroid dysfunction in mice. Renal and hepatic lipid peroxidation (LPO)was induced by the administration of carbon tetrachloride (CCl4) for 2 weeks (2.0 gm/kgtwice a week). In two separate groups, along with CCl4 animals were also treated with eitherlornit (200 mg/kg) or silymarin (100 mg/kg) every day for the same duration. Other than hepaticand renal LPO, alterations in the concentrations of serum triiodothyronine (T3), thyroxine(T4), glucose and insulin and in hepatic type-1 iodothyronine 5’monodeiodinase (5’DI)activity were considered as major parameters. Simultaneously activities of serum aspartateaminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphahatase (ALP) andhepatic and renal superoxide dismutase (SOD), catalase (CAT) and reduced glutathione content(GSH) were also studied. Lornit or silymarin administration reversed almost all the toxiceffects exhibited by CCl4 including enhanced tissue LPO, serum ALT, AST and ALP activitiesand the concentrations of insulin and glucose. Both test drugs also significantly increasedhepatic 5’DI activity, cellular antioxidants such as SOD, CAT and GSH and serum levels ofboth the thyroid hormones.
机译：本研究旨在揭示迄今未知的两种常用的肝保护药物，L-鸟氨酸-L-天冬氨酸（氯雷尼）和水飞蓟素在调节小鼠肾脏毒性和甲状腺功能异常中的功效。通过施用四氯化碳（CCl4）2周（每周两次2.0 gm / kg）诱导肾和肝脂质过氧化（LPO）。在两个独立的组中，动物也与CCl4一起每天接受氯雷尼（200 mg / kg）或水飞蓟素（100 mg / kg）的相同处理时间。除肝和肾LPO以外，血清三碘甲状腺素（T3），甲状腺素（T4），葡萄糖和胰岛素的浓度以及1型肝甲状腺素甲状腺素5’单十二烷基碘酶（5’DI）的活性被认为是主要参数。同时还研究了血清天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），碱性磷酸酶（ALP）和肝和肾脏超氧化物歧化酶（SOD），过氧化氢酶（CAT）和降低的谷胱甘肽含量（GSH）的活性。 Lornit或水飞蓟素的给药可以逆转CCl4表现出的几乎所有毒性作用，包括增强的组织LPO，血清ALT，AST和ALP活性以及胰岛素和葡萄糖的浓度。两种测试药物还可以显着提高肝脏的5'DI活性，细胞抗氧化剂（如SOD，CAT和GSH）以及甲状腺激素的血清水平。

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  • 作者

    Jatwa Rameshwar; Kar Anand;

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  • 年度 2008
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  • 正文语种 eng
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