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Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies

机译：颗粒物空气污染对C反应蛋白的影响：流行病学研究综述

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摘要

Inflammatory response is implicated as a biologic mechanism that links particulate matter (PM) air pollution with health effects. C-reactive protein (CRP), an important acute-phase reactant with profound proinflammatory properties, is used clinically as an indicator of the presence and intensity of inflammation. In vitro and in vivo animal studies suggest that CRP levels increase in response to PM exposure, but there was no consistency in epidemiologic studies. Herein, a systematic review was conducted to examine the association between PM exposure and serum CRP levels in humans. Elevated CRP levels were consistently found among children, and CRP elevations were also observed among healthy adults, albeit requiring higher peak levels of PM exposure. PM-induced CRP responses were not consistently found in adults with chronic inflammatory conditions, perhaps because of the use of anti-inflammatory medications in this population. Of the eight examined randomized trials, only one trial with a longer intervention period supported the effect of PM exposure on CRP concentrations. To provide conclusive evidence, further epidemiologic studies are needed to better quantify the magnitude of CRP level changes in response to PM with well-defined study populations and better control of various confounding factors.
机译：炎症反应被认为是将颗粒物（PM）空气污染与健康影响联系在一起的生物机制。 C反应蛋白（CRP）是一种重要的急性期反应物，具有深厚的促炎特性，在临床上被用作指示炎症的存在和强度的指标。体外和体内动物研究表明，CRP水平随PM暴露而增加，但在流行病学研究中并不一致。在这里，进行了系统的审查，以检查人体中PM暴露与血清CRP水平之间的关系。尽管要求较高的PM暴露峰值水平，但在儿童中始终发现CRP升高，在健康成年人中也观察到CRP升高。在患有慢性炎症的成年人中未始终发现PM诱导的CRP反应，这可能是因为在该人群中使用了抗炎药物。在八项检查的随机试验中，只有一项干预期较长的试验支持PM暴露对CRP浓度的影响。为了提供确凿的证据，需要进行进一步的流行病学研究，以更好地量化CRP水平变化的幅度，以明确定义的研究人群对PM的反应并更好地控制各种混杂因素。

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