Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus

S. Snelling J. S. Sinsheimer; A. Carr and J. Loughlin

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Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus

机译：LRCH1作为骨关节炎易感基因座的遗传关联分析

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Objective. A genetic association with knee osteoarthritis (OA) of a single nucleotide polymorphism (SNP) in intron 1 of the LRCH1 gene was recently reported in a UK Caucasian case-control sample and confirmed in a Newfoundland Caucasian sample. Our objective was to assess whether the SNP was associated with OA in our large UK Caucasian sample.

机译：目的。最近在英国高加索病例对照样本中报道了LRCH1基因内含子1的单核苷酸多态性（SNP）与膝骨关节炎（OA）的遗传关联，并在纽芬兰高加索样本中得到证实。我们的目的是评估我们的大型英国高加索样本中SNP是否与OA相关。

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《Rheumatology》 |2007年第2期|250-252|共3页
作者
S. Snelling J. S. Sinsheimer; A. Carr and J. Loughlin;
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University of Oxford Nuffield Department of Orthopaedic Surgery Institute of Musculoskeletal Sciences Botnar Research Centre Oxford UK and;

Departments of Human Genetics and Biomathematics David Geffen School of Medicine at UCLA Los Angeles CA 90095-1766 USA;

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1. Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus. [J] . Snelling S, Sinsheimer JS, Carr A, Rheumatology . 2007,第2期

机译：LRCH1作为骨关节炎易感基因位点的遗传关联分析。
2. Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility. [J] . Jiang Q, Shi D, Nakajima M, Journal of human genetics . 2008,第1期

机译：LRCH1中的单核苷酸多态性与膝骨关节炎易感性缺乏关联。
3. EPIGENETIC AND TRANSCRIPTIONAL EFFECTS OPERATE ON THE SUPT3H AND RUNX2 GENES RESIDING AT THE CHROMOSOME 6P21.1 OSTEOARTHRITIS SUSCEPTIBILITY LOCUS AND CORRELATE WITH THE ASSOCIATION SIGNAL [J] . Rice S. J., Aubourg G., Sorial A. K., Osteoarthritis and cartilage . 2017,第Suppla1期

机译：表观遗传和转录作用在留在6p21.1骨关节炎敏感性轨迹处的supt3h和runx2基因上运作，与关联信号相关联
4. COMPELLING ASSOCIATION OF ASPARTIC ACID REPEAT POLYMORPHISM IN THE ASPORIN GENE WITH KNEE OSTEOARTHRITIS SUSCEPTIBILITY IN HAN CHINESE POPULATION [C] . Dongquan Shi, Qing Jiang, Long Yi, 第四届国际后基因组生命科学技术学术论坛 . 2006

机译：汉族人群中膝骨骨关节炎易感性迫使山梨蛋白基因中的ASPA酸重复多态性关联
5. Genetic dissection of murine lupus susceptibility locus SLE1C identifies estrogen-related receptor gamma as a novel regulator of autoimmunity. [D] . Perry, Daniel James. 2011

机译：小鼠狼疮易感基因座的遗传解剖SLE1C确定雌激素相关受体γ是自身免疫的新型调节剂。
6. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 [O] . Evangelos Evangelou, Ana M. Valdes, Hanneke J.M Kerkhof, -1

机译：全基因组关联研究的meta分析证实为膝关节骨性关节炎的易感位点在7q22染色体
7. Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility [O] . Jiang, Q., Shi, D., Nakajima, M., 2008

机译：LRCH1单核苷酸多态性与膝关节骨性关节炎易感性缺乏关联

Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus

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