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首页> 外文期刊>Rheumatology >Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus.
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Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus.

机译：LRCH1作为骨关节炎易感基因位点的遗传关联分析。

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OBJECTIVE: A genetic association with knee osteoarthritis (OA) of a single nucleotide polymorphism (SNP) in intron 1 of the LRCH1 gene was recently reported in a UK Caucasian case-control sample and confirmed in a Newfoundland Caucasian sample. Our objective was to assess whether the SNP was associated with OA in our large UK Caucasian sample. METHODS: The SNP was genotyped in 1521 cases that had undergone elective joint replacement of the hip (1098 cases), of the knee (340 cases) or of the hip and knee (83 cases) due to end-stage primary OA. The SNP was also genotyped in 736 controls of similar ages in the cases. RESULTS: There was no significant difference (all P-values >0.05) in genotype or allele frequencies between our cases and our controls. There was also no significant difference when the cases were stratified by sex, by joint replaced or by sex combined with joint replaced. CONCLUSION: Our data on 2257 individuals implies that the LRCH1 intron 1 SNP is not a risk factor for OA aetiology of theknee or of the hip in our UK Caucasian sample.
机译：目的：最近在英国高加索病例对照样本中报道了LRCH1基因内含子1的单核苷酸多态性（SNP）与膝骨关节炎（OA）的遗传关联，并在纽芬兰高加索样本中得到证实。我们的目的是评估我们的大型英国高加索样本中SNP是否与OA相关。方法：对1521例因末期原发性OA而行髋关节置换术（1098例），膝关节置换术（340例）或髋膝关节置换术（83例）的SNP进行了基因分型。在这些病例中，在736名年龄相似的对照中也对SNP进行了基因分型。结果：我们的病例与对照组之间的基因型或等位基因频率没有显着差异（所有P值均> 0.05）。当按性别，关节置换或性别结合关节置换对病例进行分层时，也没有显着差异。结论：我们对2257名个体的数据表明，在我们的英国高加索人样本中，LRCH1内含子1 SNP并不是导致膝或髋关节炎OA病因的危险因素。

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