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Review of Research Trends and Methods in Nano Environmental, Health, and Safety Risk Analysis

机译：纳米环境，健康与安全风险分析研究趋势与方法综述

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Despite the many touted benefits of nanomaterials, concerns remain about their possible environmental, health, and safety (EHS) risks in terms of their toxicity, long-term accumulation effects, or dose-response relationships. The published studies on EHS risks of nanomaterials have increased significantly over the past decade and half, with most focused on nanotoxicology. Researchers are still learning about health consequences of nanomaterials and how to make environmentally responsible decisions regarding their production. This article characterizes the scientific literature on nano-EHS risk analysis to map the state-of-the-art developments in this field and chart guidance for the future directions. First, an analysis of keyword co-occurrence networks is investigated for nano-EHS literature published in the past decade to identify the intellectual turning points and research trends in nanorisk analysis studies. The exposure groups targeted in emerging nano-EHS studies are also assessed. System engineering methods for risk, safety, uncertainty, and system reliability analysis are reviewed, followed by detailed descriptions where applications of these methods are utilized to analyze nanomaterial EHS risks. Finally, the trends, methods, future directions, and opportunities of system engineering methods in nano-EHS research are discussed. The analysis of nano-EHS literature presented in this article provides important insights on risk assessment and risk management tools associated with nanotechnology, nanomanufacturing, and nano-enabled products.
机译：尽管纳米材料具有许多被吹捧的好处，但它们在毒性，长期累积效应或剂量反应关系方面仍存在潜在的环境，健康和安全（EHS）风险。在过去的十五年中，已发表的有关纳米材料EHS风险的研究显着增加，其中大部分集中在纳米毒理学上。研究人员仍在学习纳米材料对健康的影响以及如何就其生产做出对环境负责的决定。本文介绍了有关纳米EHS风险分析的科学文献，以描绘该领域的最新发展并为未来的发展方向绘制图表。首先，针对过去十年发表的纳米EHS文献对关键词共现网络进行了分析，以确定纳米风险分析研究中的知识转折点和研究趋势。还评估了新兴纳米EHS研究中的目标暴露人群。审查了用于风险，安全性，不确定性和系统可靠性分析的系统工程方法，然后详细描述了利用这些方法的应用来分析纳米材料EHS风险的方法。最后，讨论了纳米EHS研究的趋势，方法，未来方向以及系统工程方法的机会。本文介绍的纳米EHS文献分析为与纳米技术，纳米制造和纳米产品相关的风险评估和风险管理工具提供了重要见解。

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