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首页> 外文期刊>Risk analysis >Physiological Daily Inhalation Rates for Health Risk Assessment in Overweight/Obese Children, Adults, and Elderly
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Physiological Daily Inhalation Rates for Health Risk Assessment in Overweight/Obese Children, Adults, and Elderly

机译：超重/肥胖儿童，成人和老年人健康风险评估的每日生理吸入率

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Physiological daily inhalation rates reported in our previous study for normal-weight subjects 2.6-96 years old were compared to inhalation data determined in free-living overweight/obese individuals (n = 661) aged 5-96 years. Inhalation rates were also calculated in normal-weight (n = 408), overweight (n = 225), and obese classes 1, 2, and 3 adults (n = 134) aged 20-96 years. These inhalation values were based on published indirect calorimetry measurements (n = 1,069) and disappearance rates of oral doses of water isotopes (i.e.,~ 2H_2O and H_2~(18)O) monitored by gas isotope ratio mass spectrometry usually in urine samples for an aggregate period of over 16,000 days. Ventilatory equivalents for overweight/obese subjects at rest and during their aggregate daytime activities (28.99 ± 6.03 L to 34.82 ± 8.22 L of air inhaled/L of oxygen consumed; mean ± SD) were determined and used for calculations of inhalation rates. The interindividual variability factor calculated as the ratio of the highest 99th percentile to the lowest 1st percentile of daily inhalation rates is higher for absolute data expressed in mVday (26.7) compared to those of data in m~3/kg-day (12.2) and m~3/m~2-day (5.9). Higher absolute rates generally found in overweight/obese individuals compared to their normal-weight counterparts suggest higher intakes of air pollutants (in μg/day) for the former compared to the latter during identical exposure concentrations and conditions. Highest absolute mean (24.57 m~3/day) and 99th percentile (55.55 m~3/day) values were found in obese class 2 adults. They inhale on average 8.21 m~3 more air per day than normal-weight adults.
机译：将我们先前研究中报告的2.6-96岁正常体重受试者的每日生理吸入率与5-96岁的自由生活超重/肥胖个体（n = 661）中确定的吸入数据进行比较。还计算了20-96岁的正常体重（n = 408），超重（n = 225）和肥胖的1级，2级和3级成年人（n = 134）的吸入率。这些吸入值基于已公布的间接量热法测量值（n = 1,069）和通常通过尿液同位素比值质谱法监测的尿液样品中口服水同位素（即〜2H_2O和H_2〜（18）O）的消失率。总期限超过16,000天。确定了超重/肥胖受试者在静息时和在其白天的总体活动中的通气当量（28.99±6.03 L至34.82±8.22 L吸入的空气/ L消耗的氧气；平均值±SD），并用于计算吸入率。以mVday（26.7）表示的绝对数据与以m〜3 / kg-day的数据（12.2）和以mVday表示的绝对数据相比，以每日吸入率的最高99％与最低的1％的比率计算的个体间变异性因子更高。 m〜3 / m〜2天（5.9）。与同等体重的肥胖者相比，超重/肥胖个体中的绝对率更高，这表明在相同的暴露浓度和条件下，前者的空气污染物摄入量高于后者（以微克/天计）。在肥胖的2级成年人中，最高绝对平均值（24.57 m〜3 /天）和第99个百分点（55.55 m〜3 /天）。他们每天比正常体重的成年人多吸入8.21 m〜3的空气。

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