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Facial Emotion Processing in Schizophrenia: A Meta-analysis of Functional Neuroimaging Data

机译：精神分裂症的面部情绪处理：功能性神经影像数据的荟萃分析

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Background: People with schizophrenia have difficulty with emotion perception. Functional imaging studies indicate regional brain activation abnormalities in patients with schizophrenia when processing facial emotion. However, findings have not been entirely consistent across different studies. Methods: Activation likelihood estimation (ALE) meta-analyses were conducted to examine brain activation during facial emotion processing in patients with schizophrenia, controls, and patients compared with controls. Secondary meta-analyses were performed to assess the contribution of task design and illness chronicity to the results reported. Results: When processing facial expressions of emotions, both patients with schizophrenia and healthy controls activated the bilateral amygdala and right fusiform gyri. However, the extent of activation in these regions was generally much more limited in the schizophrenia samples. When directly compared with controls, the extent of activation in bilateral amygdala, parahippocampal gyrus and fusiform gyrus, right superior frontal gyrus, and lentiform nucleus was significantly less in patients. Patients with schizophrenia, but not controls, activated the left insula. A relative failure to recruit the amygdala in patients occurred regardless of whether the task design was explicit or implicit, while differences in fusiform activation were evident in explicit, not implicit, tasks. Restricting the analysis to patients with chronic illness did not substantially change the results. Conclusions: A marked underrecruitment of the amygdala, accompanied by a substantial limitation in activation throughout a ventral temporal-basal ganglia-prefrontal cortex “social brain” system may be central to the difficulties patients experience when processing facial emotion.
机译：背景：精神分裂症患者的情感感知有困难。功能成像研究表明，在处理面部情绪时，精神分裂症患者的局部大脑激活异常。但是，不同研究之间的发现并不一致。方法：对精神分裂症患者，对照组以及与对照组进行比较的患者，在进行面部情绪处理时进行了激活可能性估计（ALE）荟萃分析，以检查大脑的激活情况。进行二级荟萃分析，以评估任务设计和疾病慢性病对报告结果的贡献。结果：在处理情绪的面部表情时，精神分裂症患者和健康对照者均激活了双侧杏仁核和右梭状回。但是，在精神分裂症样本中，这些区域的激活程度通常受到更大的限制。与对照组直接比较时，患者双侧杏仁核，海马旁回和梭状回，右上额回和半形核的活化程度明显降低。患有精神分裂症但未控制的患者激活了左岛。无论任务设计是显式的还是隐式的，在患者中都没有招募杏仁核的相对失败，而在显性而非隐式任务中，梭形激活的差异很明显。将分析仅限于慢性病患者并没有实质性改变结果。结论：杏仁核的明显不足，伴随着整个腹侧颞基底节-前额叶皮层“社交脑”系统的激活受到很大限制，这可能是患者处理面部情绪时遇到的困难的关键。

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    《Schizophrenia Bulletin》 |2010年第5期|p.1029-1039|共11页
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    Qi-yong Gong;

  • 作者单位

    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, 4A Datun Road, Beijing 100101, China;

    tel: +86-10-64836274, fax: +86-10-64836274, e-mail:;

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