INDOLE ALKALOID BIOSYNTHESIS: THE PATHWAYS LEADING TO AJMALICINE AND AJMALINE

LEIF BARLEBEN; JOACHIM STOCKIGT

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INDOLE ALKALOID BIOSYNTHESIS: THE PATHWAYS LEADING TO AJMALICINE AND AJMALINE

机译：吲哚类生物碱的合成：通往苯丙胺和阿马林的途径

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Originating from India, and dating back to the origin of Ayurvedic medicine, Rauvolfia serpentina (Sanskrit: Sarpagandha) has been a medicinal plant of significant importance, whose root drug has gone on to become therapeutically applied worldwide. In the

机译：蛇毒Rauvolfia serpentina（梵文：Sarpagandha）起源于印度，可追溯到阿育吠陀医学的起源，一直是非常重要的药用植物，其根药已在世界范围内逐渐用于治疗。在里面

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《Science and Culture》 |2008年第2期|p.71-76|共6页
作者
LEIF BARLEBEN; JOACHIM STOCKIGT;
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作者单位

Institute of Pharmacy, Department of Pharmaceutical Biology, Johannes Gutenberg-University, Staudinger Weg 5, D-55128 Mainz, Germany;

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正文语种 eng
中图分类自然科学总论;
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1. Biosynthesis of Monoterpenoid Indole Alkaloid Ajmaline Catalyzed by Novel Reductases [J] . GAO Shu-juan, Gerald von Schumann, Joachim Stoeckigt Chemical Research in Chinese Universities . 2006,第2期

机译：新型还原酶催化单萜吲哚生物碱阿玛琳的生物合成
2. Biosynthesis of Monoterpenoid Indole Alkaloid Ajmaline Catalyzed by Novel Reductases [J] . 高等学校化学研究（英文版） . 2006,第002期

机译：新型还原酶催化单萜类吲哚生物碱阿玛琳的生物合成
3. Alkaloid Biosynthesis in Rauvolfia- cDNA Cloning of Major Enzymes of the Ajmaline Pathway [J] . Martin Ruppert, Xueyan Ma, Joachim Stockigt Current organic chemistry . 2005,第15期

机译：Rauvolfia的生物碱生物合成-Ajmaline途径主要酶的cDNA克隆
4. Recursor-directed biosynthesis of unnatural novel prenylated alkaloids by exploring indole prenyltransferase [C] . CHEN Jing, MORITA Hiroyuki, LI Mei-Ying, Proceedings of the 6th CCTCNM-KSP-JSP joint symposium on pharmacognosy . 2011

机译：探索吲哚异戊二烯基转移酶的非天然新型异戊二烯生物碱的前驱体定向生物合成
5. Part I Shorter and Improved Access to the Key Tetracyclic Core of C-19 Methyl Substituted Bioactive Sarpagine-Macroline-Ajmaline Indole Alkaloids via a New Ambidextrous Asymmetric Pictet-Spengler Reaction Beginning from Either D-(+)- or L-(-)-Tryptophan Part II the Total Synthesis of a Number of Bioactive C-19 Methyl Substituted Macroline-Sarpagine Indole Alkaloids Including Macrocarpines A-g, Talcarpine, N(4)-Methyl- N(4),21-Secotalpinine, Deoxyperaksine, Dihydroperaksine, Talpinine, O-Acetyltalpinine, as Well as N(4)-Methyltalpinine [D] . Rahman, Md Toufiqur 2018

机译：第一部分通过D-（+）-或L-（-）-开始的新的两性不对称Pictet-Spengler反应，更短和更好地利用C-19甲基取代的生物活性Sarpagine-Macroline-Ajmaline吲哚生物碱的关键四环核。色氨酸第二部分，包括大果胶Ag，塔卡品平，N（4）-甲基-N（4），21-四氢松油碱，脱氧peraksines，dihydroperaksine，Talpinine，O -乙酰基talpinine以及N（4）-甲基talpinine
6. Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer’s Disease [O] . Priya Kashyap, Vivekanandan Kalaiselvan, Robin Kumar, 2020

机译：Ajmalicine和利血平：吲哚生物碱作为多靶标定向配体指向与阿尔茨海默氏病有关的因素
7. Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer’s Disease [O] . Priya Kashyap, Vivekanandan Kalaiselvan, Robin Kumar, 2020

机译：Ajmalicine和Reserpine：吲哚生物碱作为涉及阿尔茨海默病的因子的多目标定向配体

INDOLE ALKALOID BIOSYNTHESIS: THE PATHWAYS LEADING TO AJMALICINE AND AJMALINE

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