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首页> 外文期刊>Acta Ciencia Indica >DETERMINATION OF BUTORPHANOL IN PHARMACEUTICAL PREPARATIONS BY LIQUID CHROMATOGRAPHY
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DETERMINATION OF BUTORPHANOL IN PHARMACEUTICAL PREPARATIONS BY LIQUID CHROMATOGRAPHY

机译：液相色谱法测定药物制剂中的丁酚

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摘要

A reverse phase high performance liquid chromatographic method (HPLC) has been developed for the estimation of Butorphanol in its dosage forms using C_(18) column. The mobile phase (methanol, acetonitrile and acetate buffer pH 2.8) was pumped at a flow rate of 1 ml / min in the ratio of 60:30:10 and the eluents were monitored at 290 nm. The intra- and inter- day variation was found to be less than 2% showing high precision of the assay method. The mean recovery of the drug from the solution containing 200 or 300 μg/ml was 99.66 ± 1.20% indicating high accuracy. The proposed HPLC method may be used for determining Butorphanol in bulk drug samples or in pharmaceutical dosage forms.
机译：已经开发了一种反相高效液相色谱法（HPLC），用于使用C_（18）色谱柱估算其剂量形式中的布托啡诺。以1 ml / min的流速以60:30:10的比例泵送流动相（甲醇，乙腈和乙酸盐缓冲液，pH 2.8），并在290 nm处监测洗脱液。发现日内和日间变化小于2％，表明该测定方法具有很高的精确度。从浓度为200或300μg/ ml的溶液中药物的平均回收率为99.66±1.20％，表明准确性很高。提议的HPLC方法可用于测定散装药物样品或药物剂型中的布托啡诺。

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  • 来源
    《Acta Ciencia Indica》 |2009年第3期|p.363-367|共5页
  • 作者

    P. NAGARAJU; K. KRISHNACHAITHANYA; D. CHANDRABABU; V.D.N. SRINIVAS; S.V.N. PADMA;

  • 作者单位

    Deptt. of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur (A. P.), India;

    Deptt. of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur (A. P.), India;

    Deptt. of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur (A. P.), India;

    Deptt. of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur (A. P.), India;

    Deptt. of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur (A. P.), India;

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  • 正文语种 eng
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  • 关键词

    estimation; butorphanol and HPLC;

    机译：估计丁苯啡诺和HPLC;

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