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New Plasmonic Biosensors for Determination of Human Hemoglobin Concentration in Blood

机译：用于测定血液中人血红蛋白浓度的新型等离子体生物传感器

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Two new types of plasmonic biosensors are applied for detection of hemoglobinconcentration in human blood by using the angular interrogation method. The firsttype of the fiber with five layers is made by a SiO_2core surrounded by GaP, gold,Al_2O_3and hemoglobin layers. The second type of the fiber with six layers is madeby a ZBLAN core surrounded by NaF, silicon, silver, Al_2O_3and hemoglobin layers.For some thicknesses of the interior layers and for a hemoglobin concentration closeto the mean value of a male human at a laser wavelength (1.53 μm), a large figure ofmerit and maximum value of the amplitude sensitivity are obtained at an angle veryclose to the resonance angle. For the second type of the sensor, 0.0036 g/dl resolutionis obtained, which is 10% finer than the estimated detection limit (0.004 g/dl) reported very recently by using an electrochemical method. Also, our resolutionis better than the previously reported value (0.006 g/dl if the angular resolution is0.001°) by using a gold–aluminum-based surface plasmon resonance sensor.
机译：两种新型的等离子生物传感器被用于通过角度询问法检测人血中的血红蛋白浓度。具有五层的第一类纤维由被GaP，金，Al_2O_3和血红蛋白层包围的SiO_2核制成。第二种类型的六层纤维是由ZBLAN芯制成的，该ZBLAN芯被NaF，硅，银，Al_2O_3和血红蛋白层包围。内层的某些厚度和血红蛋白浓度在激光波长下均接近男性的平均值在（1.53μm）的情况下，在非常接近共振角的角度获得大的品质因数和振幅灵敏度的最大值。对于第二种类型的传感器，获得0.0036 g / dl的分辨率，这比最近使用电化学方法报告的估计检测极限（0.004 g / dl）精细10％。此外，通过使用基于金-铝的表面等离子体激元共振传感器，我们的分辨率优于先前报道的值（如果角分辨率为0.001°，则为0.006 g / dl）。

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