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New Plasmonic Biosensors for Determination of Human Hemoglobin Concentration in Blood

机译:新的血浆生物传感器,用于测定血液中的人血红蛋白浓度

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摘要

Two new types of plasmonic biosensors are applied for detection of hemoglobin concentration in human blood by using the angular interrogation method. The first type of the fiber with five layers is made by a SiO_2 core surrounded by GaP, gold, Al_2O_3 and hemoglobin layers. The second type of the fiber with six layers is made by a ZBLAN core surrounded by NaF, silicon, silver, Al_2O_3 and hemoglobin layers. For some thicknesses of the interior layers and for a hemoglobin concentration close to the mean value of a male human at a laser wavelength (1.53 μm), a large figure of merit and maximum value of the amplitude sensitivity are obtained at an angle very close to the resonance angle. For the second type of the sensor, 0.0036 g/dl resolution is obtained, which is 10% finer than the estimated detection limit (0.004 g/ dl) reported very recently by using an electrochemical method. Also, our resolution is better than the previously reported value (0.006 g/dl if the angular resolution is 0.001°) by using a gold–aluminum-based surface plasmon resonance sensor.
机译:通过使用角度询问方法将两种新型等级的血浆生物传感器应用于人血液中的血红蛋白浓度。具有五层的第一类型的纤维由由间隙,金,Al_2O_3和血红蛋白层包围的SiO_2芯制成。具有六层的第二种类型的纤维由NAF,硅,银,Al_2O_3和血红蛋白层包围的Zblan核心制成。对于内层的一些厚度和血红蛋白浓度接近在激光波长(1.53μm)处的雄性人的平均值,在非常接近的角度下获得大的振幅灵敏度的优点和最大值。共振角度。对于第二种类型的传感器,获得0.0036g / dL分辨率,其比使用电化学方法最近报道的估计检测限(0.004g / dl)比估计的检测限(0.004g / dl)更精细。此外,我们的分辨率优于先前报告的值(如果角度分辨率为0.001°),则通过使用基于金 - 铝的表面等离子体谐振传感器来更好地(如果角度分辨率为0.001°)。

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