Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Probiotics in Chronic Inflammatory Bowel Disease and the Functional Disorder Irritable Bowel Syndrome

Dirk Haller; Jean-Michel Antoine; Stig Bengmark; Paul Enck; Ger T. Rijkers; Irene Lenoir-Wijnkoop

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Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Probiotics in Chronic Inflammatory Bowel Disease and the Functional Disorder Irritable Bowel Syndrome

机译：证实益生菌有益作用的证据指南：慢性炎症性肠病和功能性肠易激综合症中的益生菌

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Ulcerative colitis and Crohn's disease, the 2 distinct idiopathic pathologies of inflammatory bowel diseases, are spontaneously relapsing, immunologically mediated disorders of the gastrointestinal tract. Selected probiotics strains have been proven to be clinically effective in maintaining remission in patients with ulcerative colitis. None of the probiotics thus far tested has been shown to be effective in induction of remission or in maintenance of remission in patients with Crohn's disease. The multispecies probiotics mixture of 8 strains seems effective in the maintenance of remission in pouchitis. Irritable bowel syndrome is a functional bowel disorder manifested by chronic, recurring abdominal pain or discomfort associated with disturbed bowel habit in the absence of structural abnormalities likely to account for these symptoms. Recently conducted appropriately powered studies with different (combinations of) probiotics show positive results on reduction of symptoms, although a considerable placebo effect is also found. Mechanistic studies aimed at pathophysiological mechanisms of inflammatory bowel diseases can identify new targets for probiotic bacteria.

机译：溃疡性结肠炎和克罗恩氏病是炎症性肠病的两种截然不同的特发性病状，是胃肠道病的复发性，免疫学自发性疾病。某些益生菌菌株已被证明在溃疡性结肠炎患者中在维持缓解方面具有临床效果。迄今未测试过任何益生菌对克罗恩病患者的缓解或维持缓解有效。 8种菌株的多物种益生菌混合物似乎在维持眼袋炎缓解中是有效的。肠易激综合症是一种功能性疾病，表现为慢性反复发作的腹痛或在缺乏结构异常的情况下与肠蠕动习惯相关的不适来解决这些症状。最近对不同的益生菌进行了适当的动力研究，尽管它们在减少上表现出积极的结果，但是还发现了安慰剂作用。针对炎症性肠病的病理生理机制的机理研究可以为益生菌确定新的靶标。

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《Journal of Nutrition》 |2010年第3期|690-697|共8页
作者
Dirk Haller; Jean-Michel Antoine; Stig Bengmark; Paul Enck; Ger T. Rijkers; Irene Lenoir-Wijnkoop;
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Chair for Biofunctionality, ZIEL-Research Center for Nutrition and Food Science, Technische Universit?t München, Freising-Weihenstephan, Germany;

Danone Research Center, Palaiseau, France;

Institute of Hepatology, University College of London, London, United Kingdom;

Department of Internal Medicine VI, University Hospital, Tübingen, Germany;

Department of Surgery, University Medical Center Utrecht and Department of Medical Microbiology and Immunology, St. Antonius Hospital, Nieuwegein, The Netherlands;

International Dairy Federation FIL-IDF, Paris, France;

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1. Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Probiotics in Chronic Inflammatory Bowel Disease and the Functional Disorder Irritable Bowel Syndrome [J] . Dirk Haller 4, Jean-Michel Antoine 5, Stig Bengmark 6, The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2010,第3期

机译：证实益生菌有益作用的证据指南：慢性炎症性肠病和功能性肠易激综合症中的益生菌
2. Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Prevention and Management of Allergic Diseases by Probiotics [J] . Marko Kalliom?ki 4, Jean-Michel Antoine 5, Udo Herz 6, The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2010,第3期

机译：证实益生菌有益作用的证据指南：益生菌预防和管理过敏性疾病
3. Quantitative Risk-Benefit Analysis of Probiotic Use for Irritable Bowel Syndrome and Inflammatory Bowel Disease [J] . Bennett William E. Jr. Drug safety: An international journal of medical toxicology and drug experience . 2016,第4期

机译：益生菌对肠易激综合症和炎症性肠病的定量风险效益分析
4. State-of-the Art Lecture: Irritable bowel syndrome: the new inflammatory bowel disease? [C] . R. C. SPILLE Falk Symposium . 2006

机译：最先进的讲座：肠易激综合征：新的炎症性肠病？
5. Genetic investigation of inflammatory bowel disease and post-infectious irritable bowel syndrome: the contribution of innate immunity candidate risk variants. [D] . Villani, Alexandra-Chloe. 2009

机译：炎症性肠病和感染后肠易激综合症的遗传调查：先天性免疫候选风险变量的贡献。
6. Are Probiotics or Prebiotics Useful in Pediatric Irritable Bowel Syndrome or Inflammatory Bowel Disease? [O] . Stefano Guandalini 2014

机译：益生菌或益生元在儿童肠易激综合症或炎症性肠病中有用吗？
7. Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Probiotics in Chronic Inflammatory Bowel Disease and the Functional Disorder Irritable Bowel Syndrome [O] . Dirk Haller, Jean-Michel Antoine, Stig Bengmark, 2010

机译：证实益生菌有益效果证据的指导：慢性炎症性肠病患者的益生菌和功能障碍肠易肠综合征

Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Probiotics in Chronic Inflammatory Bowel Disease and the Functional Disorder Irritable Bowel Syndrome

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