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首页> 外文期刊>Tobacco control >Smoking behaviour and toxin exposure during six weeks use of a potential reduced exposure product: Omni
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Smoking behaviour and toxin exposure during six weeks use of a potential reduced exposure product: Omni

机译：使用可能减少暴露的产品六周内的吸烟行为和毒素暴露：Omni

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Objective: To determine smoking behaviour, acceptability, and toxin exposure when smokers switch to the potential reduced exposure product-Omni cigarette. Design: 12 week randomised, crossover study of Omni versus own cigarettes. Participants: 19 light/ultralight and 15 regular smokers. Outcomes: Cigarettes/day, smoking topography, craving, withdrawal symptoms, urinary cotinine plus its glucuronide (total cotinine), nicotine plus its glucuronide (total nicotine), and carcinogen metabolites (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol plus its glucuronides and 1-hydroxypyrene). Results: When switched to Omni, smokers smoked the same number of cigarettes/day, smoked Omni cigarettes less intensely (total puff volume = -11%) and had slightly lower total cotinine (-18%) levels than their own cigarettes, but had a slightly greater carbon monoxide boost/cig (+21%). Craving and withdrawal ratings were similar with Omni and own cigarettes. Carcinogen metabolite levels were somewhat but not significantly lower with Omni. About half of smokers rated Omni as better for their health and about two thirds stated it was weaker and worse tasting than their own cigarettes. Conclusions: Although Omni may be an adequate behavioural and pharmacological substitute for traditional cigarettes, it may not decrease carcinogen exposure and may increase carbon monoxide. Replications with larger sample sizes and longer follow up are needed. These results indicate the need for regulation of reduced exposure and reduced risk claims.
机译：目的：确定当吸烟者转向潜在减少接触的产品-奥姆尼香烟时的吸烟行为，可接受性和毒素暴露。设计：Omni与自己的卷烟进行为期12周的随机交叉研究。参加者：19位灯光/超光照和15位定期吸烟者。结果：每天的香烟，吸烟的地形，渴望，戒断症状，​​尿可替宁加其葡糖醛酸（总可替宁），尼古丁加其葡糖苷酸（总烟碱）和致癌物代谢物（4-（甲基亚硝基氨基）-1-（3-吡啶基） -1-丁醇及其葡糖醛酸苷和1-羟基）。结果：当切换为Omni时，吸烟者每天吸烟的次数相同，吸烟Omni的强度较弱（总抽吸量= -11％），可替宁的总含量（-18％）略低于自己的香烟，但一氧化碳的增加/增加（+ 21％）。渴望和戒断的等级与Omni和自己的香烟相似。 Omni的致癌物代谢物水平有所降低，但没有明显降低。约有一半的吸烟者认为Omni的健康状况更好，约三分之二的人表示，其味道比自己的香烟弱和糟糕。结论：尽管Omni可能是传统香烟的适当行为和药理替代品，但它可能不会减少致癌物质的暴露并可能增加一氧化碳。需要更大样本量和更长随访时间的复制。这些结果表明需要对减少暴露和减少风险要求进行监管。

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