• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Traffic >Regulation of Arf Activation: the Sec7 Family of Guanine Nucleotide Exchange Factors
【24h】

Regulation of Arf Activation: the Sec7 Family of Guanine Nucleotide Exchange Factors

机译：Arf激活的调节：鸟嘌呤核苷酸交换因子的Sec7家族。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The ADP ribosylation factors (Arts) are a family of small, ubiquitously expressed and evolutionarity conserved guanosine triphosphatases that are key regulators of vesicular transport in eukaryotic cells (D'Souza-Schorey C, Chavrier P. ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol 2006;7:347-358). Although Arfs are best known for their role in the nucleation of coat protein assembly at a variety of intracellular locations, it is increasingly apparent that they are also integral components in a number of important signaling pathways that are regulated by extracellular cues. The activation of Arfs is catalyzed by a family of guanine nucleotide exchange factors (GEFs), referred to as the Sec7 family, based on homology of their catalytic domains to the yeast Arf GEF, sec7p. While there are only six mammalian Arfs, the human genome encodes 15 Sec7 family members, which can be divided into five classes based on related domain organization. Some of this diversity arises from the tissue-specific expression of certain isoforms, but all mammalian cells appear to express at least six Arf GEFs, suggesting that Arf activation is under extensive regulatory control. Here we review recent progress in our understanding of the structure, localization and biology of the different classes of Arf GEFs.
机译：ADP核糖基化因子（Arts）是一类小型的，无处不在表达且具有进化保守性的鸟苷三磷酸酶，它们是真核细胞中囊泡运输的关键调节因子（D'Souza-Schorey C，Chavrier P. ARF蛋白：在膜运输中及以后的作用） Nat Rev Mol Cell Biol 2006; 7：347-358）。尽管Arfs因其在各种细胞内位置的外壳蛋白装配体成核中的作用而广为人知，但越来越明显的是，它们也是许多重要信号通路中不可或缺的组成部分，这些通路受细胞外信号调节。基于鸟嘌呤核苷酸交换因子（GEF）家族（称为Sec7家族），基于其催化结构域与酵母Arf GEF sec7p的同源性来催化其激活。虽然只有六个哺乳动物Arfs，但人类基因组编码15个Sec7家族成员，根据相关领域的组织结构可以分为五类。这种多样性的一部分来自某些同工型的组织特异性表达，但是所有哺乳动物细胞似乎都表达至少六个Arf GEF，这表明Arf激活受到广泛的调控。在这里，我们回顾了我们对不同类别的Arf GEF的结构，定位和生物学的了解方面的最新进展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号