• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Translational Stroke Research >Microglia/Macrophage-Derived Inflammatory Mediators Galectin-3 and Quinolinic Acid are Elevated in Cerebrospinal Fluid from Newborn Infants After Birth Asphyxia
【24h】

Microglia/Macrophage-Derived Inflammatory Mediators Galectin-3 and Quinolinic Acid are Elevated in Cerebrospinal Fluid from Newborn Infants After Birth Asphyxia

机译：小胶质细胞/巨噬细胞衍生的炎性介质Galectin-3和喹啉酸在新生儿窒息后脑脊髓液中升高。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Activation of microglia/macrophages is important in neonatal hypoxic–ischemic (HI) brain injury. Based on experimental studies, we identified macrophage/microglia-derived mediators with potential neurotoxic effects after neonatal HI and examined them in cerebrospinal fluid (CSF) from newborn infants after birth asphyxia. Galectin-3 is a novel inflammatory mediator produced by microglia/macrophages. Galectin-3 is chemotactic for inflammatory cells and activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase resulting in production and release of reactive oxygen species (ROS). Matrix metalloproteinase-9 (MMP-9) is a tissue-degrading protease expressed by activated microglia in the immature brain after HI. Both galectin-3 and MMP-9 contribute to brain injury in animal models for neonatal HI. Quinolinic acid (QUIN) is a neurotoxic N-methyl-d-aspartate (NMDA) receptor agonist also produced by activated microglia/macrophages. Galectin-3 and MMP-9 were measured by ELISA and QUIN by mass spectrometry. Asphyxiated infants (n = 20) had higher levels of galectin-3 (mean (SEM) 2.64 (0.43) ng/mL) and QUIN (335.42 (58.9) nM) than controls (n = 15) (1.36 (0.46) ng/mL and 116.56 (16.46) nM, respectively), p < 0.05 and p < 0.01. Infants with septic infections (n = 10) did not differ from controls. Asphyxiated infants with abnormal outcome had higher levels of galectin-3 (3.96 (0.67) ng/mL) than those with normal outcome (1.76 (0.32) ng/mL), p = 0.02, and the difference remained significant in the clinically relevant group of infants with moderate encephalopathy. MMP-9 was detected in few infants with no difference between groups. The potentially neurotoxic macrophage/microglia-derived mediators galectin-3 and QUIN are increased in CSF after birth asphyxia and could serve as markers and may contribute to injury.
机译：小胶质细胞/巨噬细胞的激活在新生儿缺氧缺血性脑损伤中很重要。基于实验研究，我们确定了巨噬细胞/小胶质细胞来源的介体在新生儿HI后具有潜在的神经毒性作用，并在出生后窒息的新生婴儿的脑脊液（CSF）中对其进行了检查。 Galectin-3是由小胶质细胞/巨噬细胞产生的新型炎症介质。 Galectin-3对炎性细胞具有趋化性，并激活烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶，从而产生和释放活性氧（ROS）。基质金属蛋白酶9（MMP-9）是一种组织降解蛋白酶，由HI后未成熟大脑中的活化小胶质细胞表达。在新生儿HI的动物模型中，galectin-3和MMP-9均导致脑损伤。喹啉酸（QUIN）是一种神经毒性的N-甲基-d-天冬氨酸（NMDA）受体激动剂，也由活化的小胶质细胞/巨噬细胞产生。用ELISA法测定Galectin-3和MMP-9，用质谱法测定QUIN。窒息婴儿（n = 20）的半乳凝集素3（平均值（SEM）2.64（0.43）ng / mL）和QUIN（335.42（58.9）nM）高于对照组（n = 15）（1.36（0.46）ng / mL）分别为mL和116.56（16.46）nM），p 0.05，p 0.01。感染性感染（n = 10）的婴儿与对照组无差异。结果异常的窒息婴儿的半乳凝素3（3.96（0.67）ng / mL）高于正常结果的婴儿（1.76（0.32）ng / mL），p = 0.02，在临床相关组中差异仍然很明显中度脑病的婴儿。在少数婴儿中检测到MMP-9，两组之间无差异。出生窒息后，脑脊液中潜在的潜在神经毒性巨噬细胞/小胶质细胞来源的介质半乳糖凝集素3和QUIN升高，并且可以作为标记物，并可能导致损伤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号