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Imaging of Experimental Stroke Models

机译：实验性卒中模型的成像

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The ischemic penumbra is the target of acute stroke therapy. It can be approximated on diffusion/perfusion MRI as the ischemic region with abnormal perfusion and normal diffusion imaging. Using arterial spin labeling perfusion MRI and diffusion MRI, our group has studied the evolution of the diffusion/perfusion mismatch in rat stroke models. Additionally, we have evaluated the effects of high-flow oxygen on the natural history of penumbral evolution, demonstrating that high-flow oxygen “freezes” the evolution of the mismatch and allows for later beneficial use of intravenous tissue plasminogen activator (tPA). Two neuroprotective drugs, Granulocyte colony stimulating factor and a PSD95 inhibitor both impeded the evolution of the mismatch into infarcted tissue in vivo and by histological analysis. Employing a novel technique of clot imaging, our group was able to demonstrate that the combination of tPA plus Annexin-2 was superior to tPA alone in dissolving an embolus and also in reducing the extent of hypoperfused brain tissue of perfusion imaging. The use of these advanced MRI techniques in animal experiments will help to advance clinical imaging of the ischemic penumbra and hopefully contribute to the extension of the therapeutic time window in stroke patients.
机译：缺血性半影​​是急性中风治疗的目标。在弥散/灌注MRI上可以将其近似为具有异常灌注和正常弥散成像的缺血区域。我们的小组使用动脉自旋标记灌注MRI和扩散MRI研究了大鼠中风模型中扩散/灌注失配的演变。此外，我们评估了高流量氧气对半影演变的自然历史的影响，证明高流量氧气“冻结”了错配的演变，并允许以后有益地使用静脉内组织纤溶酶原激活剂（tPA）。两种神经保护药物，粒细胞集落刺激因子和PSD95抑制剂均在体内和通过组织学分析均阻止失配向梗塞组织的演变。通过使用一种新颖的凝块成像技术，我们的小组能够证明，tPA和Annexin-2的组合在溶解栓子以及减少灌注成像脑灌注不足的程度方面优于单独的tPA。这些先进的MRI技术在动物实验中的使用将有助于推进缺血性半影​​的临床成像，并有望有助于延长中风患者的治疗时间窗。

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