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首页> 外文期刊>Translational Stroke Research >Noninvasive Measurements of Cerebral Blood Flow, Oxygen Extraction Fraction, and Oxygen Metabolic Index in Human with Inhalation of Air and Carbogen using Magnetic Resonance Imaging
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Noninvasive Measurements of Cerebral Blood Flow, Oxygen Extraction Fraction, and Oxygen Metabolic Index in Human with Inhalation of Air and Carbogen using Magnetic Resonance Imaging

机译：磁共振成像法通过吸入空气和碳源对人的脑血流量，氧提取分数和氧代谢指标进行非侵入性测量

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Noninvasive magnetic resonance (MR) methods have been explored to provide quantitative measurements of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and oxygen metabolic index (OMI = CBF × OEF). In this study, we sought to evaluate whether MR measured OEF, CBF, and OMI can consistently detect the expected physiological changes in humans under normal and hyperoxic hypercapnic conditions. Nine healthy human subjects were scanned while breathing through a mask, alternating inhaled gas in a sequential order as room air, carbogen (3% CO2 mixed with 97% O2), room air, carbogen, and room air. OEF, CBF, and OMI were obtained from the whole brain, gray matter (GM), and white matter (WM) at each gas inhalation state. Similar to previous positron emission tomography findings, our study consistently demonstrated a 10–12% decrease in OEF with a 10% increase of CBF and a stable OMI during carbogen inhalation. Moreover, GM/WM ratio in CBF and OMI remained constant during air and carbogen breathing. In addition, OEF, CBF, and OMI were highly reproducible if the same inhaled gas was used. In summary, our results demonstrate that noninvasive MR measurements can provide reproducible measurements of OEF, CBF, and OMI in normal subjects under normal and altered physiological conditions.
机译：已探索出非侵入性磁共振（MR）方法来定量测量脑血流量（CBF），氧提取分数（OEF）和氧代谢指数（OMI = CBF×OEF）。在这项研究中，我们试图评估MR测量的OEF，CBF和OMI是否能在正常和高氧高碳酸血症条件下一致地检测出人类预期的生理变化。扫描了9名健康的人类受试者，当他们戴着口罩呼吸时，以室内空气，碳源（3％的CO2 与97％的O2 混合），室内的空气，碳源和房间的顺序交替吸入气体空气。 OEF，CBF和OMI是在每种气体吸入状态下从整个大脑，灰质（GM）和白质（WM）获得的。与以前的正电子发射断层扫描结果类似，我们的研究一致表明，在吸入碳源期间，OEF降低10–12％，CBF增加10％，OMI稳定。此外，在空气和碳源呼吸期间，CBF和OMI中的GM / WM比保持恒定。此外，如果使用相同的吸入气体，则OEF，CBF和OMI具有很高的重现性。总之，我们的结果表明，在正常和变化的生理条件下，正常受试者的无创MR测量可以提供OEF，CBF和OMI的可重复测量。

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