Synthesis of 1,4-benzodiazepine derivatives labeled with radioactive isotopes and determination of the structure of their metabolites

Golovenko N.Y.; Zinkovskii V.G.; Yakubovskaya L.N.

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Synthesis of 1,4-benzodiazepine derivatives labeled with radioactive isotopes and determination of the structure of their metabolites

机译：放射性同位素标记的1，4-苯并二氮杂卓衍生物的合成及其代谢物的结构测定

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Short review on the methods for synthesis of the 1,4-benzodiazepines derivatives labeled. By_11 radioactive isotopes. Labeled aminoketones, glycine derivatives or proper radicals (~3H_3C, H_3~14C, H_3~11C) for obtaining of N~1-substituted 1,4-benzodiazepines were used for the synthesis of desired products. Possibility of obtaining of their labeled analogs with the high specific radioactivity in the isotope exchange reactions (exposure in tritium gas) has been demonstrated.

机译：简短综述标记的1,4-苯并二氮杂derivatives衍生物的合成方法。 By_11放射性同位素。用于获得N〜1-取代的1,4-苯并二氮杂卓的标记的氨基酮，甘氨酸衍生物或适当的自由基（〜3H_3C，H_3〜14C，H_3〜11C）用于合成所需产物。已经证明有可能在同位素交换反应（tri气中暴露）中获得具有高比放射性的标记的类似物。

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《Украинский химический журнал》 |1999年第10期|p.34-43|共10页
作者
Golovenko N.Y.; Zinkovskii V.G.; Yakubovskaya L.N.;
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收录信息美国《科学引文索引》(SCI);
原文格式 PDF
正文语种 rus
中图分类化学;
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7. The application of HPLC to the determination of some 1,4 benzodiazepines and their metabolites in plasma. [O] . Skellern, G G, Meier, J, Knight, B I, 1978

机译：HPLC在血浆中某些1,4苯并二氮杂及其代谢物测定中的应用。

Synthesis of 1,4-benzodiazepine derivatives labeled with radioactive isotopes and determination of the structure of their metabolites

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