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首页> 外文期刊>Journal of Virology >Rescue of Epstein-Barr Virus from Somatic Cell Hybrids of Burkitt Lymphoblastoid Cells
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Rescue of Epstein-Barr Virus from Somatic Cell Hybrids of Burkitt Lymphoblastoid Cells

机译：来自Burkitt淋巴细胞细胞的体细胞杂种的Epstein-Barr病毒拯救

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A Burkitt lymphoblastoid cell line, P3J-HR-1, was fused and hybridized to a human sternal marrow cell line. The somatic cell hybrids were negative when examined for Epstein-Barr virus (EBV) markers. When the hybrid cells were exposed to 5-iododeoxyuridine, both EBV-specific antigens and virus particles were induced as determined by the immunofluorescence test and by electron microscopy. The data presented suggest that the EBV genome can be transferred from a lymphoblastoid cell to another cell type during cell hybridization, that the EBV genome can persist in the hybrid cells for long periods of time, and that synthesis of the virus can be induced in the heterokaryons.
机译：Burkitt淋巴细胞酸碱细胞系P3J-HR-1被融合并与人类胸骨细胞系杂交。当检查Epstein-Barr病毒（EBV）标记时，体细胞细胞杂种是阴性的。当杂交细胞暴露于5-碘脱氧尿苷时，诱导EBV特异性抗原和病毒颗粒，如通过免疫荧光试验和通过电子显微镜测定。提出的数据表明，在细胞杂交期间，可以将EBV基因组从淋巴细胞传递到另一种细胞类型，即EBV基因组可以长时间持续存在于杂交细胞中，并且可以在其中诱导病毒的合成异质龙。

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