首页> 外文期刊>Journal of Virology >Membrane proteins specified by herpes simplex viruses. I. Identification of four glycoprotein precursors and their products in type 1-infected cells.
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Membrane proteins specified by herpes simplex viruses. I. Identification of four glycoprotein precursors and their products in type 1-infected cells.

机译:单纯疱疹病毒指定的膜蛋白。 I.鉴定1型感染细胞中的四种糖蛋白前体及其产物。

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Polypeptide precursors to the major glycoproteins specified by herpes simplex virus type 1 were identified in immunoprecipitation experiments using antisera that reacted specifically with the viral glycoproteins and their precursors. The results demonstrate that the major glycosylated proteins detected in infected cells are derived from four antigenically distinct polypeptides. Three of these polypeptides become glycosylated in two discrete stages, yielding partially glycosylated intermediates and fully glycosylated products. The final products are the predominant species detected in cytoplasmic virions and in plasma membranes. The fourth polypeptide precursor appears to acquire very little carbohydrate and differs in several respects from the other three precursors.
机译:通过用特异性与病毒糖蛋白及其前体反应的抗血清,在免疫沉淀实验中鉴定出单纯疱疹病毒型1的主要糖蛋白的多肽前体。结果表明,在感染细胞中检测到的主要糖基化蛋白质来自四种抗原性不同的多肽。这些多肽中的三种在离散阶段中成为糖基化,从而部分糖基化的中间体和完全糖基化产物。最终产品是在细胞质病毒中和血浆膜中检测到的主要物种。第四个多肽前体似乎获得非常小的碳水化合物,并且不同于其他三体的几个方面。

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  • 来源
    《Journal of Virology》 |1976年第3期|共18页
  • 作者

    P G Spear;

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  • 收录信息 美国《科学引文索引》(SCI);
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