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首页> 外文期刊>Journal of Virology >Antigens and DNA of a chimpanzee agent related to Epstein-Barr virus.
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Antigens and DNA of a chimpanzee agent related to Epstein-Barr virus.

机译：与Epstein-Barr病毒相关的黑猩猩剂的抗原和DNA。

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摘要

Biological and biochemical studies of the herpesvirus of chimpanzees previously demonstrated to be antigenically related to human Epstein-Barr virus (EBV) indicated that the agent is similar to EBV in that: (i) leukocyte culture of chimpanzees whose sera contained antibody against EBV capsid antigen could yield long-term lymphoblastoid cell lines (Ch-LCL) with B-cell characteristics; (ii) the DNA of Ch-LCL contained sequences homologous to approximately 35 to 45% of human EBV; (iii) Ch-LCL contained an intranuclear antigen, Ch-NA, that could be identified with some chimpanzee or orangutan serum in anticomplimentary immunofluorescence assays; and (iv) treatment of Ch-LCL with iododeoxyuridine resulted in expression of new antigenic activity that reacted with EA+ but not EA- human sera. Two lines of evidence indicate that the chimpanzee agent, although related to human EBV, is a distinct agent: (i) Ch-NA was antigenically distinct from EBV-rebv infection although it cross-reacts of a limited extent with a minor component of EBNA; and (ii) Ch-LCL are missing 55 to 65% of the DNA sequences of human EBV.
机译：先前证明的黑猩猩疱疹病毒的生物化学和生化研究抗原与人对斯坦 - 巴克病毒（EBV）表明，该试剂与EBV类似：（i）黑猩猩的白细胞培养物，其血清含有EBV衣壳抗原的抗体抗体可以产生具有B细胞特征的长期淋巴细胞素细胞系（CH-LCL）; （ii）CH-LCL的DNA含有同源序列至约35-45％的人EBV; （iii）CH-LCL含有顽核抗原CH-NA，可以用抗逆综合免疫荧光测定中的一些黑猩猩或猩猩血清鉴定; （iv）与碘oxyuridinine的CH-LCL处理，导致新的抗原活性表达，与EA +但不是ea-人血清反应。两条证据表明，黑猩猩代理人虽然与人类EBV相关，但是是一种不同的试剂：（i）CH-NA抗原与EBV-REBV感染不同，尽管它与EBNA的次要成分交叉反应; （ii）CH-LCL缺失55％至65％的人EBV的DNA序列。

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