Inhibition and enhancement of phieomycin-induced DNA breakdown by aromatic tricyclic compounds

A.M. Gero; G.W. Grigg; M.J. Sleigh; W.H. Sasse

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Inhibition and enhancement of phieomycin-induced DNA breakdown by aromatic tricyclic compounds

机译：芳族霉素诱导的芳族三环化合物诱导的DNA分解的抑制和增强

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Cationlc aronatlc trlcyclic compounds including triphenylmethane dyes, phenazines, phenoxazines, acridines, pheoothiazines, phenanthridinium compounds, anthracenes and xanthene dyes, which amplify cell killing in phleomycin-treated Escherichia coli 8 cells also modified phleomycin-induced breakdown of DNA to acid-soluble fragments. A plot of DNA breakdown as a function of concentration was bell-shaped for each of the active compounds, i.e. as the concentration increased, DNA breakdown was enhanced initially, but above a certain concentration, the proportion of DNA degraded declined, often to zero. One of the compounds, acriflavine, when tested also inhibited DNA breakdown following ultraviolet irradiation. A study, by sedimentation methods, of DNA single-strand breakage in phleomycin-treated E. coli cells, using 3 representative compounds, Crystal Violet, 3,6-diaminoacridine and Methylene Blue, revealed a consistent increase in DNA strand breaks as concentration of compound increased. In similar experiments with ethidium bromide the breakage yield/concentration curve exhibited a maximum. In general, however, it seems that the inhibition of DNA-breakdown observed at higher concentrations of these amplifying compounds is not explicible by an effect on the primary breakage event, but is due to suppression of exonucleolytic activity in the cells.

机译：阳离子aronatlc甲肾上腺化合物，包括三苯基甲烷染料，苯脲素，苯氧螯合素，吖啶，斑藻，菲喹啉化合物，蒽染料，其扩增在富含霉素处理的大肠杆菌8细胞中杀死细胞杀灭的细胞猝灭，还改性了富含霉素诱导的DNA崩解于酸溶碎片。作为浓度函数的DNA分解图是用于每种活性化合物的钟形，即，随着浓度的增加，最初提高DNA击穿，但高于一定浓度，DNA降解的比例均下降，通常为零。在紫外线辐射后，测试时，测试的化合物，Acriflavine也抑制了DNA分解。通过沉淀方法，通过沉淀方法，DNA单链断裂在富含霉素处理的大肠杆菌细胞中，使用3个代表性化合物，晶体紫，3,6-二氨基吖啶和亚甲基蓝，揭示了DNA链中的一致增加，如浓度化合物增加。在溴化乙锭类似的实验中，破损产率/浓度曲线显示出最大值。然而，通常，在较高浓度的这些扩增化合物中观察到DNA击穿的抑制作用是由于初级破裂事件的影响而不可解释，而是由于抑制细胞中的外核分子活性。

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《Nucleic acids research》 |1984年第23期|共11页
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A.M. Gero; G.W. Grigg; M.J. Sleigh; W.H. Sasse;
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1. Inhibition and enhancement of phieomycin-induced DNA breakdown by aromatic tricyclic compounds [J] . A.M. Gero, G.W. Grigg, M.J. Sleigh, Nucleic acids research . 1984,第23期

机译：芳族霉素诱导的芳族三环化合物诱导的DNA分解的抑制和增强
2. Inhibition and enhancement of phieomycin-induced DNA breakdown by aromatic tricyclic compounds [J] . A.M. Gero, G.W. Grigg, M.J. Sleigh, Nucleic acids research . 1984,第23期

机译：芳族霉素诱导的芳族三环化合物诱导的DNA分解的抑制和增强
3. Effect of injection of di- and tricyclic aromatic compounds on post-combustion formation of polychlorinated dibenzo-p-dioxins and dibenzofurans [J] . Stina Jansson, Jerker Fick, Mats Tysklind The Science of the Total Environment . 2011,第18期

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4. Determining Inhibition Effects of Some Aromatic Compounds on Peroxidase Enzyme Purified from White and Red Cabbage [C] . Aykut ?ZTEK?N, Züleyha ALMAZ, Hasan ?ZDEM?R International Conference on Advances in Natural and Applied Sciences . 2016

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5. CARBOHYDRAZIDE AS A SOLID REDUCING AGENT FOR REACTION GAS CHROMATOGRAPHY (DETERMINATION OF AZO, NITRO AND SULFONATE COMPOUNDS). PART I: REACTIONGAS CHROMATOGRAPHY OF AZO COMPOUNDS BY CARBOHYDRAZIDE REDUCTION AND GAS CHROMATOGRAPHY OF THE RESULTANT COMPOUNDS. PART II: ANALYSIS OF AROMATIC NITRO COMPOUNDS AND AROMATIC SULFONATES BY CARBOHYDRAZIDE REDUCTION AND GAS CHROMATOGRAPHY OF THE RESULTANT COMPOUNDS. [D] . RAHN, PETER CHARLES. 1973

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6. Inhibition and enhancement of phleomycin-induced DNA breakdown by aromatic tricyclic compounds. [O] . G W Grigg, A M Gero, W H Sasse, 1984

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7. STUDIES ON THE SYNTHESIS OF QUINOLINE COMPOUNDS III. : Syntheses of Tricyclic Aromatic Compounds with Two Parts of 3-Carboxy-1-ethyl-4-oxo-1,4-dihydropyridine [O] . Hirao Ichiro, Yamaguchi Masahiko, Takefuji Nobuo, 1984

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8. Inhibition of DNA and RNA Polymerase Reactions by Trypanocidal Drugs. Effect of Aromatic Diamidine and Phenanthridinium Compounds [R] . Zahalsky, A. C., Brown, D. G., Nelson, N. F. 1979

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Inhibition and enhancement of phieomycin-induced DNA breakdown by aromatic tricyclic compounds

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