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首页> 外文期刊>Journal of Virology >Structure and dimorphism of c-rel (turkey), the cellular homolog to the oncogene of reticuloendotheliosis virus strain T.
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Structure and dimorphism of c-rel (turkey), the cellular homolog to the oncogene of reticuloendotheliosis virus strain T.

机译：C-Rel（土耳其）的结构和二晶，围网细胞病毒菌株T的细胞同源物。

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摘要

A locus has been identified in turkey DNA that contains nucleotide sequences homologous to the oncogene (v-rel) in the avian retrovirus, reticuloendotheliosis virus strain T. This locus, c-rel, has been molecularly cloned from an apparently heterozygous turkey. c-rel is approximately 23 kilobase pairs in length, with at least seven apparent introns, and contains sequences sufficient to account for all of v-rel. Nucleic acid sequence differences exist between v-rel and homologous regions of c-rel. We examined a population of turkeys to determine whether these sequence differences are the result of polymorphism in the population. Within the turkey population, c-rel is dimorphic in apparent introns and 3' flanking sequences, but polymorphism has not been detected within the regions of the c-rel locus that are homologous to v-rel. Additionally, no nucleic acid sequence differences have been detected between the regions of c-rel in turkeys that are homologous to v-rel and the sequences related to v-rel of a homologous locus in chickens (Chen et al., J. Virol. 245:104-113, 1983). The general organization of introns and flanking sequences is conserved for both c-rel in turkeys and this locus in chickens, indicating that c-rel, like other proto-oncogenes, may have an important development or metabolic function.
机译：在土耳其DNA中鉴定了源位DNA，其含有与禽逆转录病毒的癌基因（V-Rel）同源的核苷酸序列，网状管状病毒菌株T.该基因座，C-Rel，已从明显杂合的火鸡中克隆。 C-rel长度为约23千碱基对，具有至少七个表观内含子，并且含有足以占V-Rel的序列。核酸序列差异存在于C-Rel的V-Rel和同源区域之间。我们检查了一群火鸡，以确定这些序列差异是否是人口多态性的结果。在土耳其人口中，C-Rel在表观内含子和3'侧翼序列中的二态性，但在与V-Rel的C-Rel基因座的区域内未检测到多态性。另外，在火鸡的C-Rely的区域之间没有检测到核酸序列差异，其与V-Rel和与鸡中同源基因座相关的V-Rel相关的序列（Chen等，J.Virol。 245：104-113,1983）。在火鸡的C-Rel和鸡中的C-Rel和鸡的C-Rel，表明C-Rel，如其他原型孔子生成，可能具有重要的发育或代谢功能。

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