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首页> 外文期刊>Journal of Virology >Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens.
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Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens.

机译：内源性异卵鼠白血病病毒相关序列图到编码小鼠淋巴细胞抗原的染色体区域。

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DNAs of all inbred mouse strains contain multiple copies (18 to 28 copies per haploid mouse genome) of endogenous xenotropic murine leukemia virus-related sequences detectable by Southern analysis with a xenotropic murine leukemia virus env gene-specific probe. After PvuII digestion, we identified a subset of xenotropic murine leukemia virus-related sequences that are well resolved by agarose gel electrophoresis and can be mapped to specific chromosomes by using recombinant inbred mouse strains. Interestingly, three of six xenotropic proviral loci that we mapped were integrated near genes encoding mouse lymphocyte antigens (Ly-m22, chromosome 1; Ly-m6, chromosome 2; and Ly-m10, chromosome 19) and a fourth xenotropic proviral locus mapped near a gene on chromosome 4 that has a major influence on xenotropic virus cell surface antigen levels. These studies indicate that xenotropic proviral loci are located on many different mouse chromosomes and may be useful markers for molecularly cloning and characterizing regions of the mouse genome important in lymphocyte development.
机译：所有近交小鼠菌株的DNA含有多个拷贝（每单倍体小鼠基因组拷贝）的内源性异孔鼠白血病病毒相关序列，其南部分析与异孔鼠白血病病毒ENV基因特异性探针。在PVUII消化后，我们确定了通过琼脂糖凝胶电泳良好分解的异胞鼠白血病病毒相关序列的子集，并且可以通过使用重组近交小鼠菌株映射到特异性染色体。有趣的是，我们映射的六个异熵脱鸟位置中的三个综合靠近小鼠淋巴细胞抗原的基因（Ly-M22，染色体1; ly-M6，染色体2;和Ly-M10，染色体19）和映射附近的第四异熵玻璃轨迹染色体4的基因对异胞病毒细胞表面抗原水平具有重大影响。这些研究表明，异熵荧光局位于许多不同的小鼠染色体上，并且可以是用于分子克隆和表征在淋巴细胞发育中重要的小鼠基因组区域的有用标记。

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