首页> 外文期刊>Journal of Virology >Donation of N- or B-tropic phenotype to NB-tropic murine leukemia virus during mixed infections.
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Donation of N- or B-tropic phenotype to NB-tropic murine leukemia virus during mixed infections.

机译:在混合感染期间捐赠NB或B-热带鼠白血病病毒的NB-热带鼠白血病病毒。

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The IC isolate of Moloney murine leukemia virus (MuLV), which is NB-tropic, was grown in cells producing conditionally defective or defective virus particles derived from N- or B-tropic MuLV. The infectious MuLV that was then released was found to be sensitive to Fv-1 restriction but produced NB-tropic progeny upon passage. These results indicate that this NB-tropic MuLV can acquire sensitivity to Fv-1 restriction by phenotypic mixing with N- or B-tropic MuLV. It is thus suggested that NB-tropic MuLV is insensitive to Fv-1 restriction simply because it lacks the determinants of tropism.
机译:莫尼鼠白血病病毒(MULV)的IC分离物是Nb-Tropic的病毒(MULV)在细胞中生长在产生衍生自N-或B-热带MULV的有条件有缺陷或缺陷的病毒颗粒的细胞中。然后发现释放的传染性莫尔夫对Fv-1限制敏感,但在通过后产生Nb-热性后代。这些结果表明,这种Nb-Tropic Mulv可以通过与N-或B-热带Mulv的表型混合来获得对FV-1限制的敏感性。因此表明,Nb-Tropic Mulv对Fv-1的限制不敏感,因为它缺乏覆革主义的决定因素。

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