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首页> 外文期刊>Journal of bacteriology >Outer membrane protein e of Escherichia coli K-12 is co-regulated with alkaline phosphatase.
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Outer membrane protein e of Escherichia coli K-12 is co-regulated with alkaline phosphatase.

机译：大肠杆菌K-12的外膜蛋白E与碱性磷酸酶共调节。

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摘要

Outer membrane protein e is induced in wild-type cells, just like alkaline phosphatase and some other periplasmic proteins, by growth under phosphatase limitation. nmpA and nmpB mutants, which synthesize protein e constitutively, are shown also to produce the periplasmic enzyme alkaline phosphatase constitutively. Alternatively, individual phoS, phoT, and phoR mutants as well as pit pst double mutants, all of which are known to produce alkaline phosphatase constitutively, were found to be constitutive for protein e. Also, the periplasmic space of most nmpA mutants and of all nmpB mutants grown in excess phosphate was found to contain, in addition to alkaline phosphatase, at least two new proteins, a phenomenon known for individual phoT and phoR mutants as well as for pit pst double mutants. The other nmpA mutants as well as phoS mutants lacked one of these extra periplasmic proteins, namely the phosphate-binding protein. From these data and from the known positions of the mentioned genes on the chromosomal map, it is concluded that nmpB mutants are identical to phoR mutants. Moreover, some nmpA mutants were shown to be identical to phoS mutants, whereas other nmpA mutants are likely to contain mutations in one of the genes phoS, phoT, or pst.
机译：外膜蛋白E在野生型细胞中诱导，就像碱性磷酸酶和一些其他周质蛋白一样，通过磷酸酶限制的生长。组成蛋白质e组成的NMPA和NMPB突变体也显示为构成型成分产生周质酶碱性磷酸酶。或者，已知蛋白质E的蛋白质磷酸酶，所以已知各自的PHO，PHOL和PHOR突变体以及坑PST双突变体。此外，发现大多数NMPA突变体的周质空间和在过量的磷酸盐中生长的所有NMPB突变体都是含有至少两种新蛋白质的含有至少两种新蛋白质的，该现象是个体光和手术突变体以及坑PST双突变体。其他NMPA突变体以及PHOS突变体缺乏这些额外的周质蛋白之一，即磷酸盐结合蛋白。从这些数据和从所述染色体图的已知基因的已知位置，得出结论，NMPB突变体与Phor突变体相同。此外，显示一些NMPA突变体与PHOS突变体相同，而其他NMPA突变体可能含有一种基因PHOS，PHOL或PST中的突变。

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