Organization of viral genome in a T antigen-negative hamster tumor induced by human papovavirus BK.

Y Yogo; A Furuno; A Nozawa; S Uchida

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Organization of viral genome in a T antigen-negative hamster tumor induced by human papovavirus BK.

机译：人乳头病毒BK诱导的T抗原阴性仓鼠病毒基因组组织。

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We analyzed by blot hybridization the state and structure of the viral DNA in an exceptional BK virus-induced hamster tumor (choroid plexus papilloma Vn-324) that contains about one copy of the BK virus genome per cell, but no intranuclear T antigen as assayed by indirect immunofluorescence. The BK viral DNA was found to be integrated into cellular DNA at a site in the middle of the early region of the viral genome (between 0.32 and 0.41 map units). The structure of the inserted viral DNA shows that it cannot encode a full-size large T antigen, but may encode small T antigen and an N-terminal portion of large T antigen.

机译：我们通过印迹杂交分析了异常的BK病毒诱导的仓鼠肿瘤（脉络丛乳头瘤VN-324）中病毒DNA的状态和结构，其含有每种细胞的BK病毒基因组的一份拷贝，但没有作为测定的肿瘤抗原间接免疫荧光。发现BK病毒DNA将在病毒基因组的早期区域的位置（在0.32和0.41映射单元之间）集成到蜂窝DNA中。插入的病毒DNA的结构表明它不能编码全尺寸的大T抗原，但可以编码小T抗原和大T抗原的N末端部分。

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《Journal of Virology》 |1981年第2期|共8页
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Y Yogo; A Furuno; A Nozawa; S Uchida;
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收录信息美国《科学引文索引》(SCI);
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1. Organization of viral genome in a T antigen-negative hamster tumor induced by human papovavirus BK. [J] . Y Yogo, A Furuno, A Nozawa, Journal of Virology . 1981,第2期

机译：人乳头病毒BK诱导的T抗原阴性仓鼠病毒基因组组织。
2. Organization of viral genome in a T antigen-negative hamster tumor induced by human papovavirus BK. [J] . Y Yogo, A Furuno, A Nozawa, Journal of Virology . 1981,第2期

机译：人乳头病毒BK诱导的T抗原阴性仓鼠病毒基因组组织。
3. Integrated viral genomes can be lost from adenovirus type 12-induced hamster tumor cells in a clone-specific, multistep process with retention of the oncogenic phenotype. [J] . Pfeffer A, Schubbert R, Orend G, Virus Research: An International Journal of Molecular and Cellular Virology . 1999,第1期

机译：整合的病毒基因组可能会在克隆特异性的多步骤过程中从腺病毒12型诱导的仓鼠肿瘤细胞中丢失，并保留致癌表型。
4. Raman spectroscopic detection of early stages in DMBA-induced tumor evolution in hamster buccal pouch model: an exploratory study [C] . Avinash D. Ghanate, G. Kumar, Sneha Talathi, Photonics 2010 : Tenth international conference on fiber optics and photonics . 2010

机译：拉曼光谱法检测仓鼠颊囊模型中DMBA诱导的肿瘤进化的早期阶段：一项探索性研究
5. Genome-wide RNA-interference Screen for Human Host Factors Vital to Influenza A Virus-induced Cell Death and Viral Replication. [D] . Tran, Anh Thuy. 2013

机译：全基因组RNA干扰筛查至关重要的人类宿主因素对甲型流感病毒诱导的细胞死亡和病毒复制。
6. Organization of viral genome in a T antigen-negative hamster tumor induced by human papovavirus BK. [O] . Y Yogo, A Furuno, A Nozawa, 1981

机译：人乳头瘤病毒BK诱导的T抗原阴性仓鼠肿瘤中病毒基因组的组织。
7. Organization of viral genome in a T antigen-negative hamster tumor induced by human papovavirus BK [O] . Y Yogo, A Furuno, A Nozawa, 1981

机译：人乳头病毒BK诱导的T抗原阴性仓鼠肿瘤中的病毒基因组组织
8. Immunological and Viral Aspects of Radiation-Induced Tumors. Third Annual Report [R] . Reif, A. E. 1977

机译：放射诱导肿瘤的免疫学和病毒学方面。第三次年度报告

Organization of viral genome in a T antigen-negative hamster tumor induced by human papovavirus BK.

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