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首页> 外文期刊>Journal of Virology >Nucleotide sequence of the env-specific segment of NFS-Th-1 xenotropic murine leukemia virus.
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Nucleotide sequence of the env-specific segment of NFS-Th-1 xenotropic murine leukemia virus.

机译：NFS-TH-1异孔鼠白血病病毒的苯特异细胞序列的核苷酸序列。

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摘要

The sequence of 863 contiguous nucleotides encompassing portions of the pol and env genes of NFS-Th-1 xenotropic proviral DNA was determined. This region of the xenotropic murine leukemia virus genome contains and env-specific segment that hybridizes exclusively to xenotropic and mink cell focus-forming but not to ecotropic proviral DNAs (C. E. Buckler et al., J. Virol. 41:228-236, 1982). The unique xenotropic env segment contained several characteristic deletions and insertions relative to the analogous region in AKR and Moloney ecotropic murine leukemia viruses. Portions of an endogenous env segment cloned from a BALB/c mouse embryo gene library that had a restriction map and hybridization properties typical of xenotropic viruses (A. S. Khan et al., J. Virol. 44:625-636, 1982) were also sequenced. The sequence of the endogenous env gene was very similar to the comparable region of the NFS-Th-1 xenotropic virus containing the characteristic deletions and insertions previously observed and could represent a segment of an endogenous xenotropic provirus.
机译：确定了包含NFS-TH-1异孔荧光DNA的POL和ENV基因部分的863连续核苷酸的序列。这种异常鼠白血病病毒基因组的该区域含有和细胞特异性区段，其专门杂交到异丙酚和水貂细胞聚焦，但不是生态学透过的DNA（Ce Buckler等，J.Virol。41：228-236,1982 ）。独特的异熵环境段包含几种特征缺失和相对于Akr和Moloney Ecotropic鼠白血病病毒的类似区域的插入。从BALB / C小鼠胚胎基因库中克隆的内源性环境的部分，其具有限制性图谱和典型的异孔病毒（作为Khan等人，J.Virol。44：625-636,1982）也被测序。内源性ENV基因的序列与含有特征缺失和预先观察到的插入的NFS-TH-1异熵病毒的相当区域非常相似，并且可以代表内源性异熵潜水术的一段。

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