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中草药：英文版

中草药：英文版

中草药（CHM）是由中国医学科学院天津药物研究所和药用植物开发研究所主办的国际官方季刊。这是中药领域第一个以英文出版的专业期刊。
  • 发文量：677
  • 被引量：321
  • H指数：0
  • 开始收录时间：2009(1)
  • CNKI综合因子：0.853
  • 维普期刊影响因子： 0.811
  • 万方期刊影响因子：0.76
  • 创刊时间：2009
  • 国内刊号/CN：12-1410/R
    国际刊号/ISSN：1674-6384
  • 发行周期：季刊
    邮发代号：
  • 主管单位：天津药物研究院
    主办单位：天津药物研究院;中国医学科学院药用植物研究所
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  • 主编：Chang-xiao Liu
  • 电话：022-23006901
  • 邮箱：chm@tiprpress.com;chmtianjin@126.com;bichm@tiprpre
  • 地址：306# Huiren Road,Binhai High-tech Zone, Tianjin,China
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中草药：英文版 >2023年第4期

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  • 摘要：Objective: With the development of the society, the number of people who catch the nephrotic syndrome(NS) is going up roughly. As we all know, traditional Chinese medicine(TCM), especially Fangji Huangqi Decoction(FHD), has a long history with good curative effects on NS. However, the mechanism of FHD treating NS has not been clearly elucidated.Methods: In this study, TCMSP platform was employed to screen active compounds of each herb of Fangji Huangqi Decoction combined with literatures. Furthermore, PharmMapper and SEA were used to predict and screen the active targets of FHD, and the HOME-NCBI-GENE, GeneCards and OMIM database were used to screen the active targets of NS. The GO and KEGG pathways involved in the targets were analyzed by Clue GO. Finally, contribution index was used to screen the active ingredients of FHD in the treatment of NS.Results: After drug-likeness(DL) and bioavailability(OB) filtering, 43 compounds were selected from FHD,interacting with 85 NS-related targets. Systematic analysis of the constructed networks revealed that it was mainly involved in PI3 K-Akt signaling pathway, MAPK signaling pathway, T cell receptor signaling pathway and TNF signaling pathway. The contribution index of every active ingredient also indicated five compounds, including astragaloside IV, quercetin, glycyrrhizic acid, glycyrrhizin and fangchinoline.Conclusions: These results have successfully predicted the pharmacodynamic material basis and the mechanism efficiency of FHD in the treatment of NS.
  • 摘要：Objective To study the chemical constituents of Epimedium koreanum.Methods Separation was carried out through silica gel and Sephadex LH-20 column chromatography and HPLC method.The chemical structures were elucidated by spectroscopic method including 1D-NMR and 2D-NMR.Results A new furanflavonol glycoside(1)was isolated and identified.Conclusion Compound 1 is a new furanflavonol glycoside,and its structure is corroborated as 5,4′-dihydroxyfurano[2″,3″:7,8]flavonol 3-O-α-L-rhamnoside.
  • 摘要：Objective To evaluate the prophylaxis and therapy of Isaria felina(IF) on glycerin-induced acute renal failure(ARF) in rats.Methods Forty male Wistar rats were divided into control,model,Uremic Clearance Granule(UCG,positive control),high-and low-dose IF groups.Rats in the high-and low-dose IF groups were ig administered with 200 and 100 mg/kg IF,respectively,while rats were ig administered with 3.6 g/kg UCG successively for 7 d to establish UCG group.The rats in model,control,and drug-treated groups were im injected with 8 mL/kg 50% glycerin after drinking was quitted for 24 h to induce ARF in rats.The drugs were continued to give thereafter.The level of blood urea nitrogen(BUN) and serum creatinine(SCr) were determined 24 and 72 h after the injection of glycerin,also the kidney was dissected for pathology examination.Results Im injection with 8 mL/kg 50% glycerin could successfully induce ARF in rats.The dose of 200 mg/kg IF could reduce the high levels of BUN and SCr,and ameliorate the pathological damage of the kidney.Conclusion IF has good protective and therapeutic effects on ARF and it is a potential and valuable Chinese herb for ARF.
  • 摘要：Objective:To rapidly identify the two morphologies and chemical properties of similar herbal medicines,Blumea riparia and B.megacephala as the basis for chemical constituent analysis.Methods:UPLC-Q-Exactive-MS/MS was utilized for profiling and identification of the constituents in B.riparia and B.megacephala.Chemical pattern recognition(CPR)was further used to compare and distinguish the two herbs and to identify their potential characteristic markers.Then,an HPLC method was established for quality evaluation.Results:A total of 93 constituents are identified,including 54 phenolic acids,35 flavonoids,two saccharides,one phenolic acid glycoside,and one other constituent,of which 67 were identified in B.riparia and B.megacephala for the first time.CPR indicates that B.riparia and B.megacephala samples can be distinguished from each other based on the LC–MS data.The isochlorogenic acid A to cryptochlorogenic acid peak area ratio calculated from the HPLC chromatograms was proposed as a differentiation index for distinguishing and quality control of B.riparia and B.megacephala.Conclusion:This study demonstrates significant differences between B.riparia and B.megacephala in terms of chemical composition.The results provide a rapid and simple strategy for the comparison and evaluation of the quality of B.riparia and B.megacephala.
  • 摘要：Objective:The objective of the present study was to evaluate the antifertility activity of ether(ErCD),chloroform(CeCD)and ethyl alcohol(EyCD)extracts of the whole plant of Cynodon dactylon in female Wistar albino rats.Methods:Acute oral toxicity and an antifertility study were performed in female Wistar rats with two dose levels(200 and 400 mg/kg,orally)of EyCD.The estrogenic and progestogenic effects of EyCD were further observed by administering it to immature Wistar rats by investigations of vaginal cornification,hormonal level,uterus weight,biochemical parameters,histopathology of the uterus and deciduoma formation,respectively.Isolation of EyCD was carried out by Flash Chromatography and isolated fraction was estimated by HPLC.Results:No toxicity with any of the extract was found up to the dose of 2000 mg/kg body weight.EyCD treated rats exhibited maximum reduction in pregnancy(83.33%).Estimation of EyCD on vaginal cornification,estrogen-induced uterotrophic assay and deciduoma model demonstrated vaginal cornification,significant(P<0.01)increase in uterine weight and uterine proliferation in histopathology and reduced deciduoma formation respectively.Hormonal and biochemical parameters confirmed the above findings indicating estrogenic potential and antiprogestogenic potential of EyCD that might be attributed to the presence of phytoestrogen(apigenin)in EyCD.Conclusion:The results suggested that extracts of C.dactylon possess significant antifertility activity,which is consistent with the literature reported in folk medicine of this plant in fertility regulation.
  • 摘要：Objective: To investigate the effects of Chinese herbal formula Qinghuofu(QHF) on the migration and invasion of breast cancer MCF-7 cells and its possible molecular mechanisms, thereby providing a theoretical basis to find effective anti-cancer medicine and therapeutic targets for the treatment of anti-migration and anti-invasion of breast cancer.Methods: Breast cancer MCF-7 cells were treated with different QHF and other different reagents, CCK8 assay was used to detect the influence of the reagents on the proliferation of MCF-7 cells; Scrape migration and Transwell assay were used to quantitatively determine the migration and invasion effects of QHF and hepatocyte growth factor(HGF) on the MCF-7 cells. Subsequently, the c-Met inhibitor and its downstream ERK and PI3 K inhibitors were used to investigate the relationship between the migration and invasion of MCF-7 cells, as well as its downstream MAPK/ERK and PI3 K/Akt signaling pathways. The expression levels of HGF, c-Met, ERK, p-Akt, p-c-Met, p-ERK, p-Akt, MMP2, MMP9, and VEGF in breast cancer MCF-7 cells treated with QHF and other reagents were also examined.Results: The result indicated that formula QHF not only significantly inhibited the proliferation of MCF-7 cells, but also significantly suppressed the effects of HGF(40 ng/m L) on the proliferation and movement of MCF-7 cells, reducing the ability of the cells to invade and migrate. Western blot analysis indicated that QHF and c-Met inhibitor significantly decreased the expression of p-c-Met, p-ERK1, p-ERK2, p-Akt, MMP-2, MMP-9, and VEGF, while HGF significantly increased the expression of p-c-Met in MCF-7 cells; c-Met downstream ERK and PI3 K inhibitors also significantly decreased the expression of MMP-2, MMP-9, and VEGF in MCF-7 cells; But the difference among c-Met, PI3 K, ERK, and QHF group were not statistically significant.Conclusion: QHF can prevent the proliferation, migration, and invasion of MCF-7 cells by inhibiting the HGF/c-Met and its downstream PI3 K/Akt and MAPK/ERK signaling pathways; Thereby down-regulating the expression of HGF, p-Met, p-ERK1, p-ERK2, p-Akt, MMP-2, MMP-9, and VEGF.
  • 摘要：The reports on chemical constituents of Hyoscyamus niger were summarized.The compounds include alkaloids,saponins,lignans,coumarinolignans,flavonoids,and some other nonalkaloidal compounds.TLC,HPLC,and GC were used for the qualitative and quantitative analyses of some chemical constituents in H.niger.Modern pharmacological experiments showed that H.niger had the analgesic,anti-inflammatory,antipyretic,anticonvulsant,spasmolytic,antidiarrhoeal,antisecretory,bronchodilatory,urinary bladder relaxant,hypotensive,cardiosuppressant,vasodilator,antitumor,and feeding deterrent properties.In addition,the toxicities of this medicinal plant were also described.
  • 摘要：Objective To study the chemical constituents from Desmodium triquetrum and their antihyperlipidemic activities. Methods The constituents of D. triquetrum were isolated and purified using various column chromatographies. Their chemical structures were elucidated using extensive spectroscopic methods. The lipid-lowering effects of the isolates were evaluated in HepG2 cells. Results Nine compounds were obtained from the ethanol extract of D. triquetrum and determined to be 6′-O-cis-p-coumaroyl-3,5-dihydroxyphenyl-β-D-glucopyranoside(1), tadehaginoside(2), rutin(3), quercetin-3-O-β-D-glucopyranoside(4), quercetin-3-O-β-D-galactopyranoside(5), 6-O-(E)-p-hydroxy-cinnamoyl-β-glucose(6), 6-O-(E)-p-hydroxy-cinnamoyl-α-glucose(7), kaempferol-3-O-β-D-rutinoside(8), and 3-O-β-D-galacopyranosyl(6-1)-α-L-rhamnosyl quercetin(9). Compounds 1 and 2 significantly reduced the intracellular content of total cholesterols and triglycerides. Conclusion Compound 1 is a new phenolic compound and exhibits potent anti-hyperlipidemic activity. Additionally, compounds 6 and 7 are isolated from D. triquetrum for the first time.
  • 摘要：Objective: To investigate the antagonistic cell injury effect and molecular mechanism of scutellarin(SCU)in hypoxia reoxygenation(HR) treated human cardiac microvascular endothelial cells(HCMECs).Methods: The method of 12 h hypoxia following by 12 h reoxygenation was used to culture HCMECs in vitro to built cell injury model. The groups were divided into control group, model(HR) group, and HR + SCU(0.1 μmol/L, 1 μmol/L, and 10 μmol/L) group. The cell viability was determined by MTT, and oxidative stress was detected by malondialdehyde(MDA) levels by biochemical assay kit. Protein expression of JAK2/p-JAK2 and STAT3/p-STAT3 were evaluated by Western blot.Results: The results of MTT and MDA showed that HR decreased the cell viability(P < 0.05) and increased MDA level significantly(P < 0.05), SCU played a contrary role in these processes. Western blot analysis indicates that, the expression of JAK2 and p-JAK2, STAT3, and p-STAT3 were increased in model group when compared with control group(P < 0.05); Compared with model group, their expression were reduced by SCU(P < 0.05).Conclusion: SCU took a protective effect on HR-treated HCMECs, and the molecular mechanism may be associated with the inhibition of JAK2/STAT3 signal transduction pathway.
  • 摘要：The concept of food and medicine continuum(FMC)is traced back to Shennong’s Classic of Materia Medica(Shénnóng Bencǎo Jing in Chinese)of the 1st century(Heinrich et al.,2022),which recorded 120 herbal medicines of the‘top grade’with nourishing properties;they can be consumed for extended periods of time without obvious side effects,indicating their functional food and medicinal benefits(Xiao,2023).In recent decades,the health-promoting actions of numerous edible herbal medicines and phytometabolites therein have been scrutinized.For instance,many FMC plants,such as Panax ginseng C.A.Mey.,Camellia sinensis(Linn.)O.Ktze.,Ganoderma lucidum(Leyss.ex Fr.)Karst.,Lycium barbarum L.,etc.,display effects of enhancing immunity(Pan et al.,2023;Yao et al.,2023).The benefits of dietary interventions and phytometabolites on improving cognitive functions in elderly population have been supported by accumulating evidence(Heinrich et al.,2022).Therefore,food and medicine dual-use products are important in the prevention and intervention of chronic diseases and senile illnesses.
  • 摘要：Objective To establish a new method with near-infrared(NIR) spectroscopy to determine the total content of emodin, chrysophanol, rhein, aloeemodin, and physcion. NIR was used in this study to provide rapid and nondestructive analysis results. Methods In the first place, HPLC was used to measure the total content of emodin, chrysophanol, rhein, aloe-emodin and physcion in Rhei Radix et Rhizoma(RR) as a reference. In the second place, the spectral regions, regression methods, pretreatment methods, and partial least squares(PLS) factors were compared to increase the feasibility of the model. In the last, the root mean square error of calibration(RMSEC), root mean square error of cross validation(RMSECV), root mean square error of prediction(RMSEP), and correlation coefficient(r) were used as assessment parameters. Results PLS with first derivative pretreatment in the ranges of 4242-5581 cm^(-1), 5885-6233 cm^(-1) and 6394-7011 cm^(-1) provided the best results. The RMSEC and RMSEP obtained were 0.134 and 0.226 respectively. The according determination coefficients of the quantitative model were 0.99 and 0.94. Conclusion NIR spectroscopy as a quick and nondestructive analytical method may be used to determine the total content of emodin, chrysophanol, rhein, aloeemodin, and physcion for the quality control of RR.
  • 摘要：Objective:In Chinese herbal medicine(CHM)history,Lonicerae Japonicae Flos and Lonicerae Flos were used clinically as one drug,but now they are admitted as two herbal medicines in Chinese Pharmacopoeia(2010 edition).This study used network pharmacology to investigate whether the two can be used interchangeably for the treatment of inflammatory diseases in TCM clinical practice.Methods:Lonicerae Japonicae Flos and Lonicerae Flos were compared in the inflammation mechanism including core targets,Gene Ontology(GO),pathway and principle chemical components by the method of network pharmacology.Results:Lonicerae Japonicae Flos and Lonicerae Flos shared in six targets accounting for 66.7%of the entire core targets and more than half of the GO terms and pathways are similar.Organic acids are dominent compounds responsible for anti-inflammatory effects.Three of the compounds that bind to core targets including luteolin,quercetin and kaempferol,are shared in both herbs.Conclusion:Due to high similarity between Lonicerae Japonicae Flos and Lonicerae Flos,we believe that they can be used interchangeably for the inflammation in clinical treatment.
  • 摘要：The 3rd International Conference on the Modernization of Traditional Chinese Medicine (TCM)will be held during November 24-26, 2010, Chengdu,China, with the theme of “Traditional Chinese Medicine Innovation & Development”.
  • 摘要：Objective Herbal medicines containing toxic herbs or minerals such as Compound Danshen Tablet(CDT), Angong Niuhuang Pill(ANP), and Lidan Paishi Tablet(LPT) are avoided or used with caution for pregnant women because of potential teratogenicity. To understand their mechanism, they were chosen as model subjects for the research.Methods Zebrafish embryos were used to evaluate their potential teratogenic risk in vitro. Results All of them showed teratogenic and lethal effects in zebrafish embryos, with the EC50 values at 351, 793, and 220 μg/m L, and LC50 values at 417, 596, and 380 μg/m L, respectively. CDT and LPT, displaying week potential teratogenicity as their teratogenicity indexes were greater than 1, induced tail malformation and cardiac edema mainly in zebrafish embryos, respectively. Conclusion The results provide the significant guidance of clinical safety of medication.
  • 摘要：Objective:The aim of the present study was to determine the quality marker(Q-Markers)of Sparganii Rhizoma against thrombus through an integration of investigations on its antithrombotic effect,content determination and spectrum-effect correlation analysis.Methods:Based on the concept of Q-Marker,Sparganii Rhizoma was investigated for the identification of chemical component.The pharmacological effects on arachidonic acid-induced thrombosis in zebrafish were also investigated.The material basis in ethanol extract was determined by HPLC-UV.Furthermore,the potential Q-Markers were analyzed and predicted according to the effect-chemical correlation analysis.Finally,the anti-thrombotic Q-Markers were verified through the anti-thrombotic test of monomer components.Results:The model of thrombosis zebrafish was established with larvae exposed to 100 mmol/L arachidonic acid for 1 h.Nine ingredients in Sparganii Rhizoma were identified as 5-hydroxymethylfurfural,vanillic acid,ferulic acid,p-hydroxybenzaldehyde,p-hydroxybenzoic acid,vanillin,protocatechuic acid,p-coumaric acid and isoferulic acid.According to the determination effect of zebrafish thrombosis model and HPLC content analysis results,all the other contents present positive correlation except 5-hydroxymethylfurfural,and the P values of three representative potential Q-Markers(ferulic acid,protocatechuic acid and p-coumaric acid)were 0.002,0.001 and 0.026,respectively.Conclusion:Sparganii Rhizoma showed a dose-dependent effect on the recovery of reducing cardiac red blood cell on zebrafish model.Three phenolic acids(ferulic acid,protocatechuic acid and p-coumaric acid)were proved to possess the anti-thrombotic effects which could be regarded as the potential QMarkers for quality assessment of Sparganii Rhizoma.
  • 摘要：Chinese medicine is a very big concept of medicine. In Shennong era, medicine and food do not divide."Medicine and food homology", which is called "Chinese medicine and dietary application", refers to that many foods are drugs, and there is no absolute demarcation line between them. At that time, seventy poisons were encountered in a day for experimental accusations, herbal medicines are divided into upper, middle and lower categories,
  • 摘要：Objective Pinoresinol di-glucopyranoside(PDG) is one of the main active lignans of Eucommiae Cortex considered to be a high-quality antihypertensive drug. In this study the pharmacokinetic process of PDG and its primary in vivo metabolite pinoresinol glucoside(PG) in the portal and jugular vein were surveyed and evaluated simultaneously. Methods A sensitive high-performance liquid chromatography coupled with tandem quadruple mass spectrometry(HPLC-MS/MS) method and sample preparation protocol were developed and validated in method of selectivity, sensitivity, precision, stability, and extraction recovery for the simultaneous determination of PDG and its primary metabolite PG in rat plasma. The double intubation technique was used to simultaneously collect blood from common jugular vein and hepatic portal vein after single ig administration of PDG. Results Using this method, the quantification linearity ranges of PDG and PG in rat plasma were both 0.05-100 ng/mL. This method was successfully applied to the evaluation of the absolute oral bioavailability of PDG and determination of the pharmacokinetic properties of PDG and PG after ig administration of single dose in rats. The bioavailability of PDG at common jugular vein was 51.3% compared to that of 91.6% at hepatic portal vein. Conclusion We conclude that liver is the major conversion site of PDG to PG.
  • 摘要：Objective To investigate the possible protective effects of sophocarpine on mucosal injury and epithelial barrier disruption on dextran sulfate sodium(DSS)-induced acute colitis. Methods Male BALB/c mice were randomly divided into three groups. The mice in normal group were given normal water, and those in model and sophocarpinetreated groups were given 2.5% DSS for 6 d to induce acute colitis. Sophocarpine(30 mg/kg) was ip administered once daily during the study period. Severity of colitis was evaluated by disease activity index(DAI), histological injury and inflammatory cytokine production including tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), and monocyte chemoattractant protein-1(MCP-1). The colonic barrier disruption was assessed by testing the expression of junctional adhesion molecule-1(JAM-1), E-cadherin(E-CAD), and desmocollin-2(DSC-2) in colon mucosa. Expression of HNF4α in colon mucosa was detected by immunohistochemistry staining and real-time RT-PCR, respectively. Results Compared with normal group, DAI, colonic shortening, and histopathological injury in model group were elevated(P < 0.05), but reduced in sophocarpine-treated group(P < 0.05). Compared with model group, the m RNA expression of inflammatory cytokines(TNF-α, IL-1β, MCP-1) were obviously lower in sophocarpine-treated group(P < 0.05), while the cellular junction proteins(E-CAD, JAM-1, and DSC-2) were higher(P < 0.05). The expression of HNF4α at m RNA and protein levels was decreased significantly in model group, but increased apparently in sophocarpine-treated group. Conclusion Sophocarpine can enhance the expression of HNF4α, promote the expression of colonic intrecellular junctions, thus, maintain the integrity of the colonic barrier and inhibit the colitis process. We suggest that sophocarpine could enhance the production of cellular junction proteins to protect the intestinal barrier fuction, at least partly, in HNF4α-dependent pathway.
  • 摘要：Edible bird’s nest(EBN)is a kind of natural invigorant with a long history of consumption in Asia,especially in China.EBN is formed by mixing the saliva of swiftlets(Aerodramus)with feathers and other components during the breeding season.Proteins are the most important nutrient in EBN.By studying proteins in EBN,we can not only elucidate their components at the molecular level,but also study their bioactivities.Therefore,it is of great significance to study the proteins in EBN.Previous research on the proteins in EBN was preliminary and cursory,and no one has summarized and analyzed the proteins in EBN and correlated the bioactivities of these proteins with the biological functions of EBN.This article focused on the proteins in EBN,listed the proteins identified in different proteomic studies,and introduced the sources,structures and bioactivities of the most frequently identified proteins,including acidic mammalian chitinase,lysyl oxidase homolog 3,mucin-5AC,ovoinhibitor,nucleobindin-2,calciumbinding protein(MW:4.5×10~4)and glucose-regulated protein(MW:7.8×10~4).The properties of these proteins are closely related to the bioactivities of EBN.Therefore,this article can provide inspiration for further research on the efficacy of EBN.
  • 摘要：Objective: Crude Leonuri Fructus(CLF), the fruits of the Leonurus japonicus Houtt, and processed Leonuri Fructus(PLF) by stir-baking as the important Chinese herbal medicines, have been used in China and other Asian countries for thousands of years. The objective of this research is to reveal the difference between CLF and PLF.Methods: The sensory technologies of the colorimetry, sensitive and validated HPLC-ELSD and GC combined with flame ionization detector(GC-FID) were employed to discriminate CLF and its processed product PLF. The color parameters of the samples were determined by colorimetric instrument CR-410. Moreover, the content of stachydrine and six fatty acids were determined by HPLC and GC. Subsequently,analysis of variance(ANOVA), principal components analysis(PCA), hierarchical cluster analysis(HCA),and Kendall's correlation test were performed for data analysis.Results: The CLF and PLF were divided into two categories by PCA and HCA in terms of their component content and color. The results distinctly demonstrated significant changes in color and the content of indicative components between CLF and PLF.Conclusion: The study revealed that HPLC, GC, and colorimetric method in combination with chemometric method could be used as comprehensive quality evaluation for CLF and PLF.
  • 摘要：Chinese Herbal Medicines(CHM)is an official international journal sponsored by Tianjin Institute of Pharmaceutical Research and Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences.The purpose of CHM is to provide a forum for the studies on Chinese herbal medicines,phytomedicines,and natural products as well.The journal will accept the following contributions:letters,original articles,review papers,short communications.
  • 摘要：Objective To investigate the inhibitory mechanism of emodin on lipopolysaccharide (LPS)-induced nitric oxide (NO) generation in rat peritoneal macrophages. Methods NO production and iNOS expression were measured through nitrite assay and Western blotting assay, respectively. NF-κB activity and nuclei P65 expression were estimated by dual-luciferase and Western blotting assay, respectively. Intracellular free Ca2+ ([Ca2+]i) was detected using the ratiometric fluorescent calcium indicator dye, Fura-2, and a microspectrofluorometer. PLC-γ phosporylation was analyzed by Western blotting assay. Results First, emodin was found playing active roles in suppressing LPS-induced NF-κB activation in rat peritoneal macrophages. Second, emodin down-regulated transient [Ca2+]i and could increase in NF-κB upstream signal. Finally, emodin suppressed phosphorylation of PLC-γ by LPS stimulation in the upstream of [Ca2+]i. Conclusion Suppression of PLC-γ phosphorylation is involved in emodin inhibiting NO generation by LPS stimulation in rat peritoneal macrophages.
  • 摘要：Engelhardia is a genus of seven species of trees in the family Juglandaceae,native to southeast Asia.In China,the genus is mainly distributed in Guangdong,Hainan,Guangxi,Guizhou,Yunnan and other places.The genus name is commonly misspelled"Engelhardtia",a"correction"made by the original author Carl Ludwig Blume in 1829 was used until today,as it was thus entered in the Index Kewensis;the original spelling is Engelhardia.
  • 摘要：Chinese Traditional and Herbal Drugs (CTHD),also known as Zhongcaoyao,was founded in January 1970. There are 40 volumes,near 500 issues including supplemental to 2009 have been published. In 1992 it was awarded national core publication published in Chinese and kept the title to date via four times reevaluations at 1996,2000, 2004,and 2008. As one
  • 摘要：Objective To establish a new procedure for isolating scutellarin from Erigeron multiradiatus. Methods A proposed method was developed by combining macroporous resins with ODS column. Firstly, E. multiradiatus was extracted by ultrasound with 80% methanol. Preliminary separation was performed on macroporous resin column.The performance and adsorption characteristics of three macroporous resins, D140, D141, and D605, were compared and the enrichment procedure was optimized. Further purification was carried out by medium pressure liquid chromatography(MPLC) with ODS column. Results It was demonstrated that D141 had better extractive effects on scutellarin. The MPLC conditions were optimized as follows: 15% ethanol aqueous as mobile phase with flow rate at2.5 mL/min. The yield and purity of the isolated scutellarin were 1.20 mg/g and 96.5%, respectively. Conclusion The overall procedure is efficient and low-cost, which is considered suitable for the separation and purification of scutellarin from E. multiradiatus. The results provide the scientific basis for developing and using scutellarin in clinic.
  • 摘要：Objective Ovalitenin A(1-(4-methoxybenzofuran-5-yl)-3-phenyl-2-propen-1-one) is a chalcone isolated from Millettia pulchra. The aim of the study was to investigate the antitumor effect of ovalitenin A on apoptosis in vitro and in vivo and to identify the mechanism involved. Methods The effect of ovalitenin A in human cervical cancer HeL a cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay, morphological observation, flow cytometric measurement, Western blotting, and xenograft model. Results Ovalitenin A inhibited the proliferation of He La cells in a dose-dependent manner in vitro and in vivo and induced the apoptosis evidenced by characteristic apoptotic morphological changes, phosphatidylserine externalization, and activation of caspase-3. In addition, ovalitenin A induced G2/M cell cycle arrest and up-regulation of the Bax/Bcl-2 ratio. Furthermore, ovalitenin A decreased protein level of COX-2 and induced the loss of mitochondrial membrane potential. Conclusion These data suggest that ovalitenin A has the potential of anticancer properties for the treatment of cervical cancer.
  • 摘要：Objective To assess the effectiveness and safety of traditional Chinese medicine(TCM)for women with diminished ovarian reserve(DOR).Methods A literature search was conducted in eight electronic databases for randomized controlled trials.Results Seventeen randomized controlled trials involving 1174 patients were included.Meta-analysis indicated that TCM was superior to Western medicine(WM)in reducing basal serum FSH level[MD=-1.70,95%CI(-2.63,-0.77);P=0.0004]and FSH/LH(MD=-0.43,95%CI[-0.56,-0.30];P=0.0001),and the effect was more obvious two months after the last treatment(MD=-4.60,95%CI[-6.26,-2.90],P<0.000 01 and MD=-0.56,95%CI[-0.85,-0.28],P=0.0001),and increasing antral follicle count(AFC)(MD=0.44,95%CI[0.04-0.83];P=0.03).The review also revealed the positive role of CMM as an adjuvant to IVF-ET in improving pregnancy rate(PR=1.75,95%CI[1.25,2.46];P=0.001).Conclusion TCM,with its unique way of replenishing the kidney,may provide an effective and safe alternative therapy to patients with DOR.
  • 摘要：In recent years,the development of Chinese herbal medicine(CHM)has been challenged by shortages of CHM resources and drug safety concerns related to end products.There have been significant efforts by Chinese scholars to tackle these challenges,which are revealed by analyzing the research trend of CHM resources via surveying Chinese Traditional and Herbal Drugs(Zhong Cao Yao),a representative journal in CHM.Our study focused on 781 articles in CHM resources from 2013 to 2018 and included four subject areas:germplasm resources,quality analysis and evaluation,cultivation,and bioengineering of CHM.Discussion and prospective for future investigations were also presented,including:construct the core germplasm of medicinal plants and expand germplasms;combine molecular research with field experiments and promote the deeper study of cultivation of CHM plants;improve the quality evaluation method of CHM and strengthen the identification of Chinese patented medicines;promote the sustainable development of CHM resources by utilizing bioengineering and synthetic biology.This study helps international scholars understand the status quo of CHM research and provides theoretical support for the healthy,modern,and international development of CHM,and it will facilitate the sustainable development of the traditional Chinese medicine industry.
  • 摘要：Objective: Gentamicin(GM) is a commonly used aminoglycoside antibiotic, however, renal toxicity has limited its usage. The present study was designed to evaluate the ameliorative effect of Cistanche deserticola on GM-induced nephrotoxicity in rats.Methods: The nephrotoxicity in rats was induced by intraperitoneal administration of GM(100 mg/kg)for 10 consecutive days. Glomerular filtration rate, blood urea nitrogen, creatinine and kidney histopathology were detected to assess the GM-induced nephrotoxicity. The oxidative stress(catalase,superoxide dismutase, glutathione and malondialdehyde) was assessed. The inflammatory response(tumor necrosis factor-a, interleukin-6, myeloperoxidase and nuclear factor-kappa B) and apoptotic marker(Bax and Bcl-2) were also evaluated.Results: The results showed that water and 75% ethanol extracts of C. deserticola(named CDW and CDE,respectively)(100, 200 and 400 mg/kg) in combination with GM could recover the reduction of glomerular filtration rate and enhance the renal endogenous antioxidant capability induced by GM. The increase in the expression of renal inflammatory cytokines(tumor necrosis factor-a and interleukin-6), nuclear protein of nuclear factor-kappa B(p65) and the activity of myeloperoxidase induced by GM was significantly decreased upon CDW or CDE treatment. In addition, CDW or CDE treatment could decrease the Bax protein expression and increase the Bcl-2 protein expression in GM-induced nephrotoxicity in rats significantly.Conclusion: The study demonstrated that C. deserticola treatment could attenuate kidney dysfunction and structural damage in rats induced by GM through the reduction of inflammation, oxidative stress and apoptosis.
  • 摘要：Objective To develop a qualitative and quantitative simultaneous determination of multiple bioactive constituents in total alkaloid in Sophora alopecuroides(TASA).Methods In the experiment,a new and simple HPLC-DAD method for the simultaneous determination of multiple constituents in TASA was developed.The separation was performed on a Kromasil C18 column(250 mm×4.6 mm,5.0μm)eluted with 0.02 mol/L potassium dihydrogen phosphate(adjusted pH 4.3 using 1%glacial acetic acid)and acetonitrile(75:25)at a flow-rate of 0.7 mL/min.The detection wavelength was set at 210 nm.Results Five constituents(sophoridine,matrine,oxymatrine,aloperine,and lehmannine)were simultaneously analyzed in this study.Four of them were identified and determinated by the developed method.The calibration curves exhibited linear regressions(r 2 >0.9995).The injection precision,the intra-day precision,and the analysis repeatability were validated with the RSD values less than 5.0%.The mean recoveries of the four constituents were ranged from 98.62%to 100.20%,and the RSD values were all less than 3.37%.Conclusion This method is convenient,fast,accurate,and is applicable to analyze the multi-constituents in TASA.

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