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Hyponatremia and syndrome of inappropriate anti-diuretic hormone reported with the use of Vincristine: an over-representation of Asians?

机译：使用长春新碱报道低钠血症和抗利尿激素不当综合征：亚洲人人数过多吗？

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PURPOSE: This retrospective study used a pharmaceutical company's global safety database to determine the reporting rate of hyponatremia and/or syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) among vincristine-treated patients and to explore the possibility of at-risk population subgroups. METHOD: We searched the Eli Lilly and Company's computerized adverse event database for all reported cases of hyponatremia and/or SIADH as of 1 November 1999 that had been reported during the use of vincristine. RESULTS: A total of 76 cases of hyponatremia and/or SIADH associated with vincristine use were identified. The overall reporting rate was estimated to be 1.3/100,000 treated patients. The average age of patients was 35.6 +/- 28.3 years, and 62% were males. Approximately 75% of the patients were receiving treatment for leukemia or lymphoma. Among the 39 reports that included information on race, the racial distribution was: 1 Black, 3 Caucasian, and 35 Asian. CONCLUSION: Our data suggest that Asian patients may be at increased risk of hyponatremia and/or SIADH associated with vincristine use. Although the overall reported rate of SIADH associated with vincristine is very low, physicians caring for Asian oncology patients should be aware of this potential serious but reversible adverse event.
机译：目的：这项回顾性研究使用了一家制药公司的全球安全数据库来确定长春新碱治疗的患者中的低钠血症和/或抗利尿激素分泌异常综合征的报告率，并探讨高危人群的可能性。方法：我们搜索了礼来公司的计算机不良事件数据库，以查找截至1999年11月1日在使用长春新碱期间报告的所有低钠血症和/或SIADH病例。结果：共鉴定出76例与长春新碱有关的低钠血症和/或SIADH病例。总体报告率估计为1.3 / 100,000受治疗的患者。患者的平均年龄为35.6 +/- 28.3岁，其中62％为男性。大约75％的患者正在接受白血病或淋巴瘤的治疗。在包括种族信息的39份报告中，种族分布为：1黑人，3白人和35亚洲。结论：我们的数据表明，亚洲患者使用长春新碱可能会增加发生低钠血症和/或SIADH的风险。尽管与长春新碱相关的SIADH的总体报告比率非常低，但是照顾亚洲肿瘤患者的医生应意识到这种潜在的严重但可逆的不良事件。

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