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首页> 外文期刊>Pharmacoepidemiology and drug safety >Antihypertensive drug treatment in a Swedish community: Skaraborg Hypertension and Diabetes Project.
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Antihypertensive drug treatment in a Swedish community: Skaraborg Hypertension and Diabetes Project.

机译：瑞典社区的降压药物治疗：Skaraborg高血压和糖尿病项目。

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摘要

PURPOSE: To describe and compare the pattern of antihypertensive drug prescriptions during different time periods. METHODS: Antihypertensive prescriptions were registered in all patients who underwent an annual follow-up during 1998 (n = 984), 1992-1993 (n = 924), and 1981 (n = 689), at the hypertension outpatient clinic in primary health care, Skara, Sweden. RESULTS: From 1981 to 1998 the total prescriptions of thiazides declined from 61 to 10% (p < 0.001), whilst prescriptions of calcium antagonists increased from 4 to 30% (p < 0.001), and ACE inhibitors from zero to 23% (p < 0.001). Prescriptions of calcium antagonists and ACE inhibitors increased during 1990-1995, but during 1996-1998 a significant decrease in primary prescriptions of calcium antagonists was demonstrated (OR: 0.15; 95% CI: 0.06-0.36). During all periods, females were more frequently treated with older types of antihypertensive drugs than males. In the analysis of total prescriptions in 1998 women were prescribed calcium antagonists(OR: 0.59; 95% CI: 0.45-0.78) and ACE inhibitors (OR: 0.43; 95% CI: 0.31-0.58) less frequently than men. CONCLUSION: There were significant changes in type of antihypertensive drugs used, both by time and between genders. Changes during the latest years indicate that the prescription pattern can be greatly influenced by new scientific reports and economic debate.
机译：目的：描述和比较不同时期的降压药处方模式。方法：在1998年（n = 984），1992-1993年（n = 924）和1981年（n = 689）的一级门诊就诊的所有年度随访患者中均注册了降压处方。 ，瑞典斯卡拉。结果：从1981年到1998年，噻嗪类药物的总处方量从61％下降到10％（p <0.001），而钙拮抗剂的处方量从4％增加到30％（p <0.001），而ACE抑制剂的处方量从零增加到23％（p <0.001）。钙拮抗剂和ACE抑制剂的处方在1990-1995年期间有所增加，但是在1996-1998年期间，钙拮抗剂的主要处方被证明显着减少（OR：0.15; 95％CI：0.06-0.36）。在所有期间，与男性相比，女性更常使用较旧类型的降压药治疗。在1998年的总处方分析中，女性服用钙拮抗剂（OR：0.59; 95％CI：0.45-0.78）和ACE抑制剂（OR：0.43; 95％CI：0.31-0.58）的频率低于男性。结论：所使用的降压药类型在时间和性别上都有显着变化。最近几年的变化表明，处方模式可能会受到新的科学报告和经济辩论的极大影响。

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