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首页> 外文期刊>Pharmacoepidemiology and drug safety >Psychotropic drugs and fatal pulmonary embolism.
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Psychotropic drugs and fatal pulmonary embolism.

机译：精神药物和致命性肺栓塞。

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PURPOSE: To examine the association between the use of psychotropic drugs and fatal pulmonary embolism. METHODS: We conducted a national case-control study of fatal pulmonary embolism. Cases were 75 New Zealand men and women aged 15-59 years who died between 1 January 1990 and 31 December 1998, where the underlying cause of death was certified as codes 415.1, 451 or 453 of the International Classification of Diseases (9th Revision). Four controls, matched for sex and age, were selected from the general practice to which each case had belonged. Information was abstracted from the records of general practitioners, family planning clinics and psychiatric services. Odds ratios and 95% confidence intervals (95% CI) were estimated using conditional logistic regression. The key analyses were restricted to cases (n = 62) and controls (n = 243) without major risk factors for venous thromboembolism. RESULTS: Compared to non-use, the adjusted odds ratio for current use of antipsychotic drugs was 13.3 (95% CI: 2.3-76.3). Low potency antipsychotics appeared to carry the highest risk (odds ratio: 20.8 [95% CI: 1.7-259.0]). The main drug involved was thioridazine. The odds ratio for current use of antidepressants was also increased, at 4.9 (95% CI: 1.1-22.5). CONCLUSIONS: Our results for conventional antipsychotics are consistent with previous studies of non-fatal venous thromboembolism. The finding for antidepressants needs to be replicated in other studies.
机译：目的：探讨使用精神药物与致命性肺栓塞之间的关系。方法：我们进行了致命性肺栓塞的国家病例对照研究。病例为75名年龄在15-59岁之间的新西兰男性和女性，他们在1990年1月1日至1998年12月31日期间死亡，其基本死因经国际疾病分类（第9版）的编码415.1、451或453认证。从每个病例所属的一般实践中选择了四个性别和年龄相匹配的对照。从全科医生，计划生育诊所和精神科服务的记录中提取信息。使用条件逻辑回归估计赔率和95％置信区间（95％CI）。关键分析仅限于无主要血栓栓塞风险因素的病例（n = 62）和对照（n = 243）。结果：与未使用药物相比，当前使用抗精神病药物的调整优势比为13.3（95％CI：2.3-76.3）。低效抗精神病药似乎具有最高风险（赔率：20.8 [95％CI：1.7-259.0]）。涉及的主要药物是硫代哒嗪。当前使用抗抑郁药的几率也增加了，为4.9（95％CI：1.1-22.5）。结论：我们对常规抗精神病药的研究结果与先前对非致命性静脉血栓栓塞的研​​究一致。抗抑郁药的发现需要在其他研究中重复。

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