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Preventing adverse drug events in hospital practice: an overview.

机译:在医院实践中预防不良药物事件:概述。

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摘要

Adverse drug events (ADEs) are a considerable cause of morbidity and mortality in hospital practice. The precise frequency is unknown, but studies give an incidence number ranging from 2 until 52 ADEs per 100 patients. There are many different methods for definition, causality assessment, severity classification and detection which make it difficult to compare the different studies. A substantial part (in some studies up to 70%) of ADEs can be prevented and it is important to, besides their detection, focus on the prevention of these ADEs. In this literature review we give an overview of methods for preventing ADEs. There are many different tools with different impact on a particular part of the distribution system which has the potential to prevent ADEs. A multifaceted approach is needed. Two interesting strategies of prevention, pharmacist participation on ward rounds and computerised physician order entry with clinical decision support systems (CDSS), are highlighted. Moreover, two promising CDSS are discussed in more detail, namely computer-based monitoring systems and information systems which link laboratory and pharmacy data.
机译:药物不良反应(ADEs)是医院实践中发病和死亡的重要原因。确切的频率是未知的,但是研究给出了每100名患者2到52 ADEs的发生率。定义,因果关系评估,严重性分类和检测的方法很多,这使得比较不同研究变得困难。可以预防相当一部分(在某些研究中高达70%)的ADEs,除了对其进行检测之外,还应重点关注预防这些ADEs。在这篇文献综述中,我们概述了预防ADE的方法。有许多不同的工具对分发系统的特定部分有不同的影响,这些工具有可能阻止ADE。需要一种多方面的方法。重点介绍了两种有趣的预防策略:药剂师参与病房检查以及使用临床决策支持系统(CDSS)进行计算机医师订单输入。此外,将更详细地讨论两个有前途的CDSS,即基于计算机的监视系统和链接实验室和药房数据的信息系统。

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