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首页> 外文期刊>Chemical engineering journal >Porous three-dimensional scaffolds made of mineralised collagen: Preparation and properties of a biomimetic nanocomposite material for tissue engineering of bone
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Porous three-dimensional scaffolds made of mineralised collagen: Preparation and properties of a biomimetic nanocomposite material for tissue engineering of bone

机译：由矿化胶原蛋白制成的多孔三维支架：用于骨组织工程的仿生纳米复合材料的制备和性能

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摘要

For healing of bone defects and as matrix for tissues engineering, porous scaffolds are required that can be easily pre-seeded with cells in the lab and invaded by tissue after implantation. We have developed porous 3D scaffolds consisting of mineralised collagen type I-a nanocomposite, which mimics the composition of extracellular matrix of healthy bone tissue. The steps of material processing as well as the physico-chemical, structural and mechanical properties of this biomaterial are described in detail. The technology of differential scanning calorimetry, which provides an excellent possibility to investigate collagen-based materials, was used to characterise the final scaffold and all its intermediates in situ. Furthermore, the interconnecting porosity of the scaffolds with pore diameters of about 200 μm has been shown to be highly suitable for homogenous cell seeding, demonstrated with human marrow stromal cells.
机译：为了修复骨缺损并作为组织工程的基质，需要多孔支架，这些支架可以在实验室中轻松地预先植入细胞，并在植入后被组织侵入。我们已经开发了由矿化的I型胶原纳米复合材料组成的多孔3D支架，该支架模仿了健康骨骼组织的细胞外基质的组成。详细介绍了该生物材料的材料加工步骤以及其理化，结构和机械性能。差示扫描量热法技术为研究基于胶原的材料提供了极好的可能性，被用于原位表征最终的支架及其所有中间体。此外，具有人的骨髓基质细胞证明，具有约200μm的孔径的支架的互连孔隙率非常适合于均质细胞接种。

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