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首页> 外文期刊>Physiology & behavior >Serotonin transporter binding and acquired obesity -- an imaging study of monozygotic twin pairs.
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Serotonin transporter binding and acquired obesity -- an imaging study of monozygotic twin pairs.

机译：血清素转运蛋白结合和获得性肥胖-单卵双胞胎对的成像研究。

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Serotonin (5-HT) has been implicated as one factor controlling body weight and feeding behaviour. We studied the association between obesity and 5-HT by investigating the brain serotonin transporter (SERT) binding in 16 monozygotic twin pairs with varying body mass index (BMI) differences. The radioligand [(123)I]nor-beta-CIT was used for single photon emission computed tomography (SPECT) imaging of SERT binding. SERT genotype was also identified for each subject. We hypothesized reduced SERT binding in twins with higher BMI as compared to their leaner co-twins, and increased SERT binding in subjects with LL homozygotes compared to LS heterozygotes and SS homozygotes. In pairwise analyses, twins with higher BMI had higher SERT binding than their leaner co-twins in the hypothalamus/thalamus (specific binding ratios 1.21+/-0.23 vs. 1.12+/-0.16, p=0.04). The difference was striking in women (1.17+/-0.24 vs. 1.04+/-0.16, p=0.01), but not in men (1.26+/-0.22 vs. 1.22+/-0.08, p=0.61). In individuals, no correlation between SERT binding and BMI was evident, and no differences were found in SERT binding between the three SERT genotypes. Our finding suggests an association between acquired obesity and the 5-HT system, particularly in women. However, this association was seen only in twin data, where genetic effects and many shared environmental factors are eliminated.
机译：血清素（5-HT）被认为是控制体重和喂养行为的一个因素。我们通过研究16个单卵双胞胎对中具有不同体重指数（BMI）差异的脑血清素转运蛋白（SERT）结合，研究了肥胖与5-HT的相关性。放射性配体[（123）I]nor-β-CIT用于SERT结合的单光子发射计算机断层扫描（SPECT）成像。还为每个受试者鉴定了SERT基因型。我们假设与瘦双胞胎相比，BMI较高的双胞胎的SERT结合减少，而与LS杂合子和SS纯合子相比，LL纯合子的SERT结合增加。在成对分析中，在下丘脑/丘脑中，BMI较高的双胞胎的SERT结合率高于其瘦双胞胎（特异性结合率1.21 +/- 0.23对1.12 +/- 0.16，p = 0.04）。女性的差异显着（1.17 +/- 0.24 vs. 1.04 +/- 0.16，p = 0.01），但男性没有差异（1.26 +/- 0.22 vs. 1.22 +/- 0.08，p = 0.61）。在个体中，SERT结合与BMI之间没有明显关联，并且在三种SERT基因型之间的SERT结合中也没有发现差异。我们的发现表明，获得性肥胖与5-HT系统之间存在关联，尤其是女性。但是，这种关联仅在双胞胎数据中才能看到，其中消除了遗传效应和许多共有的环境因素。

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