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首页> 外文期刊>Physiology & behavior >The emulsified lipid Fabuless (Olibra) does not decrease food intake but suppresses appetite when consumed with yoghurt but not alone or with solid foods: A food effect study
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The emulsified lipid Fabuless (Olibra) does not decrease food intake but suppresses appetite when consumed with yoghurt but not alone or with solid foods: A food effect study

机译：乳化脂质Fabuless（Olibra）不会减少食物摄入量，但与酸奶一起食用而不是与单独或固体食物一起食用时会抑制食欲：一项食物效果研究

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The lipid emulsion Fabuless (Olibra) has been shown in some studies to decrease short/medium term energy intake (EI) and prevent weight regain. The purported mechanism is the ileal brake. Whether Fabuless is efficacious under a range of dietary conditions is unknown since studies have administered the emulsion within a fermented, semi-liquid dairy yoghurt, and outcomes have been inconsistent. To determine whether Fabuless suppresses post-ingestive satiety and short-term food intake under a range of dietary conditions and forms we administered the emulsion co-presented with 185 mL water, stirred into a semi-liquid dairy yoghurt, and co-presented with a solid food breakfast muffin. This was a cross-over study in 18 lean men randomised to 6 treatments: (i) lipid emulsion, LE (15. g Fabuless, containing 4.2. g lipid, 0.2. MJ) + water, (ii) lipid control, LC (15. g non-emulsified lipid/water, containing 4.2. g lipid, 0.2. MJ) + water, (iii) lipid emulsion + yoghurt, LE + Y (1.2. MJ), (iv) lipid control + yoghurt, LC + Y (1.2. MJ), (v) lipid emulsion + muffin, LE + M (1.2. MJ), (vi) lipid control + muffin, LC + M (1.2. MJ), each given as a test breakfast at 8.30. am. Participants rated postprandial appetite sensations using visual analogue scales (VAS), and ad libitum energy intake was measured at a lunch meal 3.5. h later. The lipid emulsion increased fullness compared with an energy-matched lipid control but only when administered within the semi-liquid fermented yoghurt (P < 0.05). There were no effects on satiety ratings when co-presented with water or with the solid food muffin. Energy and macronutrient intake were not significantly decreased by any of the emulsion treatments. We conclude that effects are small, the format in which lipid emulsions are consumed influences postprandial satiety, and there is no evidence that this emulsion alters eating behaviour at the subsequent meal.
机译：在一些研究中已显示脂质乳清无脂（Olibra）可减少短期/中期的能量摄入（EI）并防止体重增加。所谓的机制是回肠制动。 Fabuless在多种饮食条件下是否有效是未知的，因为研究已经在发酵的半液体乳制品酸奶中施用了乳化剂，并且结果不一致。为了确定Fabuless在一系列饮食条件和饮食形式下是否能抑制食后感和短期食物摄入，我们将乳状液与185毫升水共同给药，搅拌至半液体乳制品酸奶中，与固体食物早餐松饼。这是一项对18位瘦男人进行的交叉研究，随机分为6种治疗方法：（i）脂质乳剂LE（15. g Fabuless，含有4.2。g脂质，0.2。MJ）+水，（ii）脂质对照，LC（ 15.克非乳化脂质/水，含4.2。克脂质，0.2。MJ）+水，（iii）脂质乳剂+酸奶，LE + Y（1.2。MJ），（iv）脂质对照+酸奶，LC + Y（1.2。MJ），（v）脂质乳剂+松饼，LE + M（1.2。MJ），（vi）脂质对照+松饼，LC + M（1.2。MJ），分别作为8.30的测试早餐。上午。参与者使用视觉模拟量表（VAS）对餐后食欲感觉进行评分，并在午餐时测量了随意摄入的能量3.5。小时后。与能量匹配的脂质对照品相比，脂质乳剂增加了饱满度，但仅在半液体发酵酸奶中施用时才具有（P <0.05）。与水或固体食品松饼同时使用时，对饱腹感评分没有影响。乳剂处理均未显着降低能量和常量营养素的摄入。我们得出的结论是，效果很小，脂质乳状液的消耗形式会影响餐后饱腹感，并且没有证据表明这种乳状液会改变随后进餐的饮食行为。

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