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Sex steroid therapy & adiposity

机译:性类固醇疗法与肥胖

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Impaired metabolism of endogenous estrogen is central to the pathogenesis of several diseases of the cardiovascular system and CNS [1]. This could be attributed to the marked variability in pharmacokinetics and pharmacodynamics of estrogen metabolism. In addition to genetic factors, gender, age and body weight might contribute to this variability [2,3]. Altered metabolism of estrogens could also influence the efficacy of exogenous estrogen therapy (ET) used for the treatment of estrogen-related diseases. Furthermore, prolonged administration or higher dose of ET might be associated with an increased risk of venous thrombosis and stroke in such patients [4].
机译:内源性雌激素代谢受损是心血管系统和中枢神经系统几种疾病发病机制的关键[1]。这可以归因于雌激素代谢的药代动力学和药效学的显着差异。除遗传因素外,性别,年龄和体重也可能导致这种变异[2,3]。雌激素代谢的改变也可能影响用于治疗雌激素相关疾病的外源雌激素疗法(ET)的功效。此外,在此类患者中,长期服用或较高剂量的ET可能与静脉血栓形成和中风的风险增加相关[4]。

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