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首页> 外文期刊>Pharmacogenomics >Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.
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Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.

机译：大腹部手术后的镇痛要求与OPRM1基因多态性基因型和单倍型有关。

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AIMS: The association between SNPs of the human OPRM1 gene encoding the micro-opioid receptor and postoperative analgesic requirements in surgical patients remains controversial. Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and TAA+A2109G) representing the four linkage disequilibrium blocks of the OPRM1 gene influences postoperative analgesic requirements. MATERIALS & METHODS: We studied 138 adult Japanese patients who underwent major open abdominal surgery under combined general and epidural anesthesia and received continuous postoperative epidural analgesia with opioids. RESULTS: The 118G homozygous (GG) patients required 24-h postoperative analgesics more than 118A homozygous (AA) and heterozygous (AG) patients. Tag SNP haplotypes also were associated with 24-h postoperative analgesic requirements. CONCLUSIONS: These results suggest that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery.
机译：目的：编码微阿片受体的人OPRM1基因的SNP与手术患者术后镇痛要求之间的关联仍存在争议。在这里，我们评估代表OPRM1基因的四个连锁不平衡模块的五个标签SNP（A118G，IVS2 + G691C，IVS3 + G5953A，IVS3 + A8449G和TAA + A2109G）中的任何一个是否影响术后镇痛要求。材料与方法：我们研究了138名成年日本患者，他们在全麻和硬膜外联合麻醉下接受了大型开放性腹部手术，并接受了持续的阿片类药物术后硬膜外镇痛。结果：118G纯合子（GG）患者需要术后24小时镇痛，超过118A纯合子（AA）和杂合子（AG）患者。标签SNP单倍型也与术后24小时镇痛需要有关。结论：这些结果表明，OPRM1基因标签SNP基因型和单倍型可以主要有助于预测接受大开腹手术的个体患者的术后镇痛需要量。

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