HIV resistance testing in the USA - a model for the application of pharmacogenomics in the clinical setting.

Blum RA; Wylie N; England T; French C

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HIV resistance testing in the USA - a model for the application of pharmacogenomics in the clinical setting.

机译：美国的HIV耐药性测试-一种在临床环境中应用药物基因组学的模型。

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Although there is debate about how and when the medical community will readily adopt pharmacogenomics into clinical practice, HIV genotyping has become an integral part of AIDS patient management in the USA since 1996. Genotyping for HIV-1 drug resistance serves as a paradigm for the way pharmacogenomics is likely to be introduced into patient care. This review discusses the unique role that HIV-1 genotype testing plays in identifying resistance in patients and how that information is used to modify therapy selection and impact the progression of disease [1]. In addition, the important issues relating to reimbursement and the cost-effectiveness of genotyping are also discussed.

机译：尽管关于医学界如何以及何时将药物基因组学迅速应用于临床实践存在争议，但自1996年以来，HIV基因分型已成为美国AIDS患者管理不可或缺的一部分。针对HIV-1耐药性的基因分型成为该方法的范例药物基因组学很可能会引入患者护理中。这篇综述讨论了HIV-1基因型测试在识别患者抵抗力中的独特作用，以及该信息如何用于修改治疗选择和影响疾病进展[1]。此外，还讨论了与报销和基因分型的成本效益有关的重要问题。

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《Pharmacogenomics》 |2005年第2期|共11页
作者
Blum RA; Wylie N; England T; French C;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Cancer resistance to treatment; Clinical; Testing; HIV; Models;

机译：癌症对治疗的抵抗性;临床;测试;HIV;模型;

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1. HIV resistance testing in the USA - a model for the application of pharmacogenomics in the clinical setting. [J] . Blum RA, Wylie N, England T, Pharmacogenomics . 2005,第2期

机译：美国的HIV耐药性测试-一种在临床环境中应用药物基因组学的模型。
2. Human immunodeficiency virus type 1 pharmacogenomics in clinical practice: relevance of HIV-1 drug resistance testing (Part 1). [J] . Patarca R, Isava A, Campo R, Journal of environmental pathology, toxicology and oncology: official organ of the International Society for Environmental Toxicology and Cancer . 2003,第3期

机译：临床实践中的人类1型免疫缺陷病毒药物基因组学：HIV-1耐药性测试的相关性（第1部分）。
3. Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society--USA Panel (see comments) [J] . Hirsch MS, Conway B, DAquila RT, JAMA: the Journal of the American Medical Association . 1998,第24期

机译：成人HIV感染者的抗逆转录病毒药物耐药性测试：对临床管理的意义。国际艾滋病学会-美国小组（见评论）
4. An Application of Gradual Reduction of Drug Dose to HIV Infection Model in Consideration of Drug Resistance and Drug Dose [C] . H. Chang, Nam H. Jo, H. Shim SICE-ICASE International Joint Conference . 2006

机译：逐步减少药物剂量对耐药剂药物剂量对HIV感染模型的应用
5. Clinical Utility of Pharmacogenomic Testing to Support Prescriptive Decision Making Among Anesthesia Providers: A Mixed-Method Study. [D] . Riddle, Jonathan Dru. 2015

机译：药物基因组学测试在麻醉提供者中支持规定性决策的临床实用性：一项混合方法研究。
6. HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing [O] . Soo-Yon Rhee, Michael R. Jordan, Elliot Raizes, 2010

机译：HIV-1耐药性突变：即时点基因型耐药性检测的潜在应用
7. M08-01: Taxane-platinum pharmacogenomic predictors of outcome in Japan-USA common arm studies in advanced non-small cell lung cancer (NSCLC): a model for testing population-related pharmacogenomics [O] . Gandara D.R., Kawaguchi T, Crowley J, 2007

机译：M08-01：紫杉烷铂药物基因组学预测因子在日美晚期非小细胞肺癌（NSCLC）共同研究中的结果：用于测试与人口相关的药物基因组学的模型
8. Long-Term Efficacy of Routine Access to Antiretrovial-Resistance Testing in HIV Type 1-Infected Patients: Results of the Clinical Efficacy of Resistance Testing Trial [R] . Wegner, S. A. , Wallace, M. R. , Aronson, N. E. , 2004

机译：HIV 1型感染患者常规获得抗逆转录病毒检测的长期疗效：耐药性试验临床疗效的结果

HIV resistance testing in the USA - a model for the application of pharmacogenomics in the clinical setting.

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