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首页> 外文期刊>Pharmacogenomics >Pharmacogenetics of folate-related drug targets in cancer treatment.
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Pharmacogenetics of folate-related drug targets in cancer treatment.

机译：叶酸相关药物靶标在癌症治疗中的药物遗传学。

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Folate metabolism is the target of two major drug groups: folate antagonists (for example, methotrexate) and thymidylate synthase inhibitors (for example, 5-fluorouracil). These agents are used in the treatment of cancer, as well as for other conditions, such as rheumatoid arthritis. High-dose cancer treatment protocols can induce a state of acute folate depletion which may lead to significant treatment-related toxicity. Polymorphisms in folate-metabolizing enzymes may modify the therapeutic effectiveness and toxicity of these drugs. This review briefly summarizes the drugs targeting the folate pathway and describes common polymorphisms in folate-metabolizing enzymes and transport proteins. Pharmacogenetic studies investigating folate-related drug targets in the treatment of colorectal cancers and hematologic malignancies will subsequently be discussed. Findings to date illustrate a potential for targeting therapy based on patients' genotypes, in order to improve outcomes and reduce toxicity. However, larger, well-designed studies are needed to confirm these early findings.
机译：叶酸代谢是两个主要药物组的目标：叶酸拮抗剂（例如甲氨蝶呤）和胸苷酸合酶抑制剂（例如5-氟尿嘧啶）。这些试剂可用于治疗癌症以及其他疾病，例如类风湿关节炎。大剂量癌症治疗方案可能会诱发急性叶酸耗竭状态，这可能导致与治疗相关的重大毒性。叶酸代谢酶中的多态性可能会改变这些药物的治疗效果和毒性。这篇综述简要总结了针对叶酸途径的药物，并描述了叶酸代谢酶和转运蛋白中常见的多态性。随后将讨论研究叶酸相关药物靶向治疗结直肠癌和血液系统恶性肿瘤的药物遗传学研究。迄今为止的发现表明了根据患者基因型进行靶向治疗的潜力，以改善疗效并降低毒性。但是，需要更大规模，设计良好的研究来确认这些早期发现。

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