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Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese

机译：Nociceptin / orphanin FQ受体基因变异与日本人吸烟状况有关

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Aim: The endogenous opioid system has been reportedly implicated in tobaccoicotine dependence. Materials & methods: We examined the genetic effects of eight SNPs in opioid receptor-related genes on smoking status and smoking-related traits in Japanese. Results: The genotypic and allelic variations of the rs2229205 SNP in the OPRL1 gene were significantly associated with smoking status, but no significant differences were found in the genetic variations of any of the SNPs with regard to smoking-related traits. The rs2229205 SNP did not show high linkage disequilibrium with the other SNPs in the linkage disequilibrium block that contained the SNP. Conclusion: The rs2229205 SNP in the OPRL1 gene may be a genetic factor that contributes to individual differences in the vulnerability to smoking in Japanese individuals.
机译：目的：据报道内源性阿片样物质系统与烟草/尼古丁依赖性有关。材料与方法：我们研究了阿片受体相关基因中8个SNP对日本人吸烟状况和吸烟相关性状的遗传影响。结果：OPRL1基因中rs2229205 SNP的基因型和等位基因变异与吸烟状态显着相关，但是任何SNP的遗传变异在吸烟相关性状上均未发现显着差异。 rs2229205 SNP在包含SNP的连锁不平衡嵌段中未与其他SNP出现高连锁不平衡。结论：OPRL1基因中的rs2229205 SNP可能是导致日本人吸烟易感性差异的遗传因素。

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